Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Ophthalmic acid (OPH), also known as ophthalmate (chemically L-γ-glutamyl-L-α-aminobutyrylglycine), is a tripeptide analog of glutathione. However, instead of the cysteine essential for many of glutathione's diverse functions, it contains L-2-aminobutyrate, a non-proteinogenic amino acid lacking the nucleophilic thiol group. Because of this, it has been widely, and incorrectly, considered an accidental byproduct of glutathione synthesis.
In 2024, an article published by the federation of European biochemistry societies compiled evidence to put forward the major hypothesis that OPH serves as a glutathione regulating tripeptide, affecting both cellular and organelle influx and efflux of GSH, as well as modulating GSH-dependent reactions and signaling.[2]
^Ophthalmic acid
^Schomakers, Bauke V.; Jillings, Sonia L.; van Weeghel, Michel; Vaz, Frédéric M.; Salomons, Gajja S.; Janssens, Georges E.; Houtkooper, Riekelt H. (2024-01-20). "Ophthalmic acid is a glutathione regulating tripeptide". The FEBS Journal. doi:10.1111/febs.17061. ISSN 1742-464X.
Ophthalmicacid (OPH), also known as ophthalmate (chemically L-γ-glutamyl-L-α-aminobutyrylglycine), is a tripeptide analog of glutathione. However, instead...
mass spectrometry. Reductive stress Glutathione synthetase deficiency Ophthalmicacid roGFP, a tool to measure the cellular glutathione redox potential...
biomedical companies also produce brands of hyaluronan for ophthalmic surgery. Native hyaluronic acid has a relatively short half-life (shown in rabbits) so...
Ophthalmic viscosurgical devices (OVDs) are a class of clear gel-like material used in eye surgery to maintain the volume and shape of the anterior chamber...
Prednisolone acetate ophthalmic suspension (eye drops) is an adrenocortical steroid product, prepared as a sterile ophthalmic suspension and used to...
molecular formula C11H19N3O6 (molar mass: 289.285 g/mol) may refer to: Ophthalmicacid Tabtoxin, or wildfire toxin This set index page lists chemical structure...
of Johnson and Johnson. A monofilament version is also made for use in ophthalmic practice. It is indicated for soft tissue approximation and ligation....
acid derivative family of nonsteroidal anti-inflammatory drugs (NSAIDs). It is primarily indicated as a pre-operative anti-miotic (in an ophthalmic solution)...
demonstration, the elimination of latanoprost acid from plasma is rapid (half-life 17 minutes) after either ophthalmic or intravenous administration. Steroid...
Isotretinoin, also known as 13-cis-retinoic acid and sold under the brand name Accutane among others, is a medication primarily used to treat severe acne...
States, with more than 11 million prescriptions. It is available as its acid or in two salts, as either diclofenac sodium or potassium. It is also widely...
Ophthalmic drug administration is the administration of a drug to the eyes, most typically as an eye drop formulation. Topical formulations are used to...
interactions with drugs taken by mouth or through any route other than topical ophthalmic are very unlikely. Corticosteroids mediate their anti-inflammatory effects...
embolization into the ophthalmic and retinal arteries can occur. Fillers are made of polysaccharides such as hyaluronic acids, a naturally occurring...
Treatment is only needed if it is causing symptoms. This may include salicylic acid, cryotherapy, chemo-based fluorouracil or bleomycin, and surgical removal...
intravenous NSAID. The Syntex company, of Palo Alto, California developed the ophthalmic solution Acular around 2006, which is currently licensed by Allergan,...
Hiroshi (1997). "A Case of Contact Dermatitis Due to Sodium Bisulfite in an Ophthalmic Solution". The Journal of Dermatology. 24 (10): 675–677. doi:10.1111/j...
hydrochloric acid (to adjust pH), and water for injection. The pH is approximately 7.5. The osmolality is approximately 300 mOsm/Kg. BSS Plus (ophthalmic irrigation...
Travoprost acid and its metabolites are mainly excreted via the kidney with a terminal half-life of 45 minutes. "Travoprost ophthalmic Use During Pregnancy"...
brimonidine's tartrate formulation in a concentration of 0.025%, as an ophthalmic vasoconstrictor under the brand name Lumify. Intended to relieve redness...
hydrate the skin. Creams containing a high percentage of urea or lactic acid have been shown to work exceptionally well in some cases. Application of...
solvent than ethanol. Vinegar, being acidic, is a better solvent for obtaining alkaloids but a poorer solvent for acidic components. For individuals who choose...
subsequently used exclusively as a topical ophthalmic solution, typically to prevent miosis during and after ophthalmic surgery. This application has been discontinued...
hyaluronic acid, a glycosaminoglycan found in various connective tissue of humans. Sodium hyaluronate is the sodium salt of hyaluronic acid. It is a glycosaminoglycan...
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