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Nuciferine information


Nuciferine
Names
IUPAC name
1,2-Dimethoxy-6aβ-aporphine
Systematic IUPAC name
(6aR)-1,2-Dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
Other names
(R)-1,2-Dimethoxyaporphine
Identifiers
CAS Number
  • 475-83-2 checkY
3D model (JSmol)
  • Interactive image
ChEMBL
  • ChEMBL464529 ☒N
ChemSpider
  • 9740 ☒N
PubChem CID
  • 10146
UNII
  • W26UEB90B7 checkY
CompTox Dashboard (EPA)
  • DTXSID40963862 Edit this at Wikidata
InChI
  • InChI=1S/C19H21NO2/c1-20-9-8-13-11-16(21-2)19(22-3)18-14-7-5-4-6-12(14)10-15(20)17(13)18/h4-7,11,15H,8-10H2,1-3H3/t15-/m1/s1 ☒N
    Key: ORJVQPIHKOARKV-OAHLLOKOSA-N ☒N
  • InChI=1/C19H21NO2/c1-20-9-8-13-11-16(21-2)19(22-3)18-14-7-5-4-6-12(14)10-15(20)17(13)18/h4-7,11,15H,8-10H2,1-3H3/t15-/m1/s1
    Key: ORJVQPIHKOARKV-OAHLLOKOBA
SMILES
  • CN(CC1)[C@]2([H])CC3=CC=CC=C3C4=C2C1=CC(OC)=C4OC
Properties
Chemical formula
C19H21NO2
Molar mass 295.376 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references

Nuciferine is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera.[1][2]

Preliminary psychopharmacological research in 1978 was unable to conclusively determine the compound's classification regarding dopamine-receptor activity.[3] On one hand, investigative studies found evidence of behavior traditionally associated with dopamine-receptor stimulation: stereotypy, increase in spontaneous motor activity, inhibition of conditioned avoidance response, and an increase in pain sensitivity resulting in an inhibition of morphine analgesia.[3] On the other hand, these early investigative studies also found evidence of behavior traditionally associated with dopamine-receptor blockade: decrease of spontaneous motor activity, chills, catalepsy, trance-like states of consciousness.[3]

  1. ^ Seligman, Sian (2023-01-13). "Blue Lotus Flower: Smoking, Tea & More". DoubleBlind Mag. Retrieved 2023-01-19.
  2. ^ Farrell, Martilias S.; McCorvy, John D.; Huang, Xi-Ping; Urban, Daniel J.; White, Kate L.; Giguere, Patrick M.; Doak, Allison K.; Bernstein, Alison I.; Stout, Kristen A.; Park, Su Mi; Rodriguiz, Ramona M.; Gray, Bradley W.; Hyatt, William S.; Norwood, Andrew P.; Webster, Kevin A. (2016). "In Vitro and In Vivo Characterization of the Alkaloid Nuciferine". PLOS ONE. 11 (3): e0150602. Bibcode:2016PLoSO..1150602F. doi:10.1371/journal.pone.0150602. ISSN 1932-6203. PMC 4786259. PMID 26963248.
  3. ^ a b c Bhattacharya, S. K.; Bose, R.; Ghosh, P.; Tripathi, V. J.; Ray, A. B.; Dasgupta, B. (1978-09-15). "Psychopharmacological studies on (--)-nuciferine and its Hofmann degradation product atherosperminine". Psychopharmacology. 59 (1): 29–33. doi:10.1007/bf00428026. ISSN 0033-3158. PMID 100809. S2CID 11847319.

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Nuciferine

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Nuciferine is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. Preliminary psychopharmacological research in 1978 was unable...

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Nelumbo nucifera

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chemistry. Both Nymphaea caerulea and Nelumbo nucifera contain the alkaloids nuciferine and aporphine.[citation needed] The genome of the sacred lotus was sequenced...

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Promethazine

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Dopamine

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Psilocybin mushroom

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Modafinil

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Ayahuasca

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Hydroxyzine

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Mescaline

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Tyrosine

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Dicycloverine

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Atropa belladonna

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Prochlorperazine

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List of dopaminergic drugs

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Aromatic compound

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Domperidone

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Toluene

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Datura stramonium

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Tricyclic antidepressant

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