Neovascularization is the natural formation of new blood vessels (neo- + vascular + -ization), usually in the form of functional microvascular networks, capable of perfusion by red blood cells, that form to serve as collateral circulation in response to local poor perfusion or ischemia.
Growth factors that inhibit neovascularization include those that affect endothelial cell division and differentiation. These growth factors often act in a paracrine or autocrine fashion; they include fibroblast growth factor, placental growth factor, insulin-like growth factor, hepatocyte growth factor, and platelet-derived endothelial growth factor.[1]
There are three different pathways that comprise neovascularization: (1) vasculogenesis, (2) angiogenesis, and (3) arteriogenesis.[2]
^Neely, Kimberly A.; Gardner, Thomas W. (1998-09-01). "Ocular Neovascularization". The American Journal of Pathology. 153 (3): 665–670. doi:10.1016/S0002-9440(10)65607-6. ISSN 0002-9440. PMC 1852998. PMID 9736014.
^Marín-García, José (2007). "11: Cardiac Neovascularization: Angiogenesis, Arteriogenesis, and Vasculogensis". Post-Genomic Cardiology (1 ed.). Academic Press. doi:10.1016/B978-0-12-373698-7.X5000-1. ISBN 978-0-12-373698-7.
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able to induce healthy neovascularization of ischemic cardiac tissues. Choroidal neovascularization Corneal neovascularization Revascularization Rubeosis...
corneal neovascularization, the suppression of enzymes can block CNV by compromising with corneal structural integrity. Corneal neovascularization can be...
Choroidal neovascularization (CNV) is the creation of new blood vessels in the choroid layer of the eye. Choroidal neovascularization is a common cause...
and is likely a precursor to retinal neovascularization. One way to distinguish IRMA from retinal neovascularization is to perform fluorescein angiography...
choroids of rat models. Argon lasers were used to induce choroidal neovascularization (CNV) in rat models. Ursodoxicoltaurine and UDCA were injected intraperitoneally...
occurs when fibrovascular tissue, caused by an injury, inflammation or neovascularization, pulls the sensory retina from the retinal pigment epithelium.[citation...
72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene. The...
rate of angiogenesis, there is an overgrowth of blood vessels called neovascularization. In the non-proliferative type, abnormal blood flow to the retina...
may occur via new branches formed between adjacent blood vessels (neovascularization), as in the eye after a retinal embolism or in the brain when an instance...
formation of endothelial cells from mesoderm cell precursors, and from neovascularization, although discussions are not always precise (especially in older...
a pigmented lesion in 1901, and Forster, who described subretinal neovascularization in 1862. It occurs due to proliferation of retinal pigment epithelium...
topical treatment for ocular neovascularization. Aganirsen is a candidate for the treatment of ocular neovascularization in patients with front of the...
RPE (geographic atrophy) and/or development of new blood vessels (neovascularization) result in the death of photoreceptors and central vision loss. In...
quadrant most commonly affected is the superotemporal (63%). Retinal neovascularization occurs in 20% of cases within the first 6–12 months of occlusion and...
degeneration, particularly age-related macular degeneration with choroidal neovascularization. Other conditions that can present with complaints of metamorphopsia...
reduce the cornea's oxygen absorption, sometimes resulting in corneal neovascularization—the growth of blood vessels into the cornea. This causes a slight...
to neovascularization. Examples of where vasculogenesis can occur in adults are: Tumor growth (see HP59) Revascularization or neovascularization after...
epithelial layer with involvement of the corneal stroma. Corneal neovascularization – excessive ingrowth of blood vessels from the limbal vascular plexus...
therapeutic candidate for treatment of such conditions as choroidal neovascularization, heart disease, and cancer. In humans, pigment epithelium-derived...
in three stages: plasmatic imbibition, capillary inosculation, and neovascularization. During the first 24 hours, the graft is initially nourished by a...
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