PEDF information

SERPINF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IMV
Identifiers
Aliases	SERPINF1, EPC-1, OI12, OI6, PEDF, PIG35, serpin family F member 1
External IDs	OMIM: 172860 MGI: 108080 HomoloGene: 1965 GeneCards: SERPINF1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	1,777,565 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	75,313,527 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; pericardium; ; canal of the cervix; ; left uterine tube; ; gallbladder; ; periodontal fiber; ; vena cava; ; right lobe of liver; ; gastric mucosa; ; adipose tissue;
	Top expressed in
	calvaria; ; molar; ; body of femur; ; ankle; ; left lobe of liver; ; aortic valve; ; ascending aorta; ; lip; ; cervix; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; serine-type endopeptidase inhibitor activity;
Cellular component	extracellular matrix; melanosome; extracellular region; basement membrane; axon; neuronal cell body; perinuclear region of cytoplasm; axon hillock; extracellular exosome; extracellular space; collagen-containing extracellular matrix;
Biological process	cellular response to retinoic acid; kidney development; human ageing; response to arsenic-containing substance; negative regulation of gene expression; cellular response to dexamethasone stimulus; negative regulation of endothelial cell migration; multicellular organism development; cellular response to cobalt ion; retina development in camera-type eye; short-term memory; negative regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of neuron projection development; ovulation cycle; negative regulation of angiogenesis; cell population proliferation; negative regulation of inflammatory response; cellular response to glucose stimulus; response to acidic pH; negative regulation of neuron death; negative regulation of endopeptidase activity; positive regulation of neurogenesis;
	Sources:Amigo / QuickGO
Orthologs
	5176
	20317
	ENSG00000132386; ENSG00000282307
	ENSMUSG00000000753
	P36955
	P97298
	NM_002615; NM_001329903; NM_001329904; NM_001329905
	NM_011340
	NP_001316832; NP_001316833; NP_001316834; NP_002606
	NP_035470
	Wikidata
View/Edit Human	View/Edit Mouse

Pigment epithelium-derived factor (PEDF) also known as serpin F1 (SERPINF1), is a multifunctional secreted protein that has anti-angiogenic, anti-tumorigenic, and neurotrophic functions. Found in vertebrates, this 50 kDa protein is being researched as a therapeutic candidate for treatment of such conditions as choroidal neovascularization, heart disease, and cancer.^[5] In humans, pigment epithelium-derived factor is encoded by the SERPINF1 gene.^[6]^[7]

^ ^a ^b ^c ENSG00000282307 GRCh38: Ensembl release 89: ENSG00000132386, ENSG00000282307 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000753 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Filleur S, Nelius T, de Riese W, Kennedy RC (Apr 2009). "Characterization of PEDF: a multi-functional serpin family protein". Journal of Cellular Biochemistry. 106 (5): 769–75. doi:10.1002/jcb.22072. PMID 19180572. S2CID 30871963.
^ "Entrez Gene: SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1".
^ Steele FR, Chader GJ, Johnson LV, Tombran-Tink J (Feb 1993). "Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family". Proceedings of the National Academy of Sciences of the United States of America. 90 (4): 1526–30. Bibcode:1993PNAS...90.1526S. doi:10.1073/pnas.90.4.1526. PMC 45907. PMID 8434014.

[refGRCh38Ensembl-1] ENSG00000282307 GRCh38: Ensembl release 89: ENSG00000132386, ENSG00000282307 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000753 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Filleur_2009-5] Filleur S, Nelius T, de Riese W, Kennedy RC (Apr 2009). "Characterization of PEDF: a multi-functional serpin family protein". Journal of Cellular Biochemistry. 106 (5): 769–75. doi:10.1002/jcb.22072. PMID 19180572. S2CID 30871963.

[6] "Entrez Gene: SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1".

[pmid8434014-7] Steele FR, Chader GJ, Johnson LV, Tombran-Tink J (Feb 1993). "Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family". Proceedings of the National Academy of Sciences of the United States of America. 90 (4): 1526–30. Bibcode:1993PNAS...90.1526S. doi:10.1073/pnas.90.4.1526. PMC 45907. PMID 8434014.

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