Necrotizing pneumonia (NP), also known as cavitary pneumonia or cavitatory necrosis, is a rare but severe complication of lung parenchymal infection.[1][2][3] In necrotizing pneumonia, there is a substantial liquefaction following death of the lung tissue, which may lead to gangrene formation in the lung.[4][5] In most cases patients with NP have fever, cough and bad breath, and those with more indolent infections have weight loss.[6] Often patients clinically present with acute respiratory failure.[6] The most common pathogens responsible for NP are Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae.[7]
Diagnosis is usually done by chest imaging, e.g. chest X-ray, CT scan. Among these CT scan is the most sensitive test which shows loss of lung architecture and multiple small thin walled cavities.[3] Often cultures from bronchoalveolar lavage and blood may be done for identification of the causative organism(s).[8]
It is primarily managed by supportive care along with appropriate antibiotics.[8] However, if patient develops severe complications like sepsis or fails to medical therapy, surgical resection is a reasonable option for saving life.[6][8]
^Sawicki, G. S.; Lu, F. L.; Valim, C.; Cleveland, R. H.; Colin, A. A. (2008-03-05). "Necrotising pneumonia is an increasingly detected complication of pneumonia in children". European Respiratory Journal. 31 (6): 1285–1291. doi:10.1183/09031936.00099807. ISSN 0903-1936. PMID 18216055.
^Tsai, Yueh-Feng; Ku, Yee-Huang (2012). "Necrotizing pneumonia". Current Opinion in Pulmonary Medicine. 18 (3): 246–252. doi:10.1097/MCP.0b013e3283521022. ISSN 1070-5287. PMID 22388585.
^ abMasters, I. Brent; Isles, Alan F.; Grimwood, Keith (July 25, 2017). "Necrotizing pneumonia: an emerging problem in children?". Pneumonia. 9 (1): 11. doi:10.1186/s41479-017-0035-0. ISSN 2200-6133. PMC 5525269. PMID 28770121.
^Scotta, Marcelo C.; Marostica, Paulo J.C.; Stein, Renato T. (2019). "Pneumonia in Children". Kendig's Disorders of the Respiratory Tract in Children. Elsevier. p. 435.e4. doi:10.1016/b978-0-323-44887-1.00025-0. ISBN 978-0-323-44887-1. S2CID 81700501.
^Widysanto, Allen; Liem, Maranatha; Puspita, Karina Dian; Pradhana, Cindy Meidy Leony (2020). "Management of necrotizing pneumonia with bronchopleural fistula caused by multidrug-resistant Acinetobacter baumannii". Respirology Case Reports. 8 (8): e00662. doi:10.1002/rcr2.662. PMC 7507560. PMID 32999723.
^Krutikov, Maria; Rahman, Ananna; Tiberi, Simon (2019). "Necrotizing pneumonia (aetiology, clinical features and management)". Current Opinion in Pulmonary Medicine. 25 (3): 225–232. doi:10.1097/mcp.0000000000000571. ISSN 1070-5287. PMID 30844921. S2CID 73507080.
^ abcChatha, Neela; Fortin, Dalilah; Bosma, Karen J (February 19, 2021). "Management of necrotizing pneumonia and pulmonary gangrene: A case series and review of the literature". Canadian Respiratory Journal. 21 (4): 239–245. doi:10.1155/2014/864159. PMC 4173892. PMID 24791253.
and 26 Related for: Necrotizing pneumonia information
Necrotizingpneumonia (NP), also known as cavitary pneumonia or cavitatory necrosis, is a rare but severe complication of lung parenchymal infection. In...
preventing the lungs from ever clearing themselves. Necrotizingpneumonia (NP), also known as cavitary pneumonia or cavitatory necrosis, is a rare but severe...
virulence. The bicomponent toxin PVL is associated with severe necrotizingpneumonia in children. The genes encoding the components of PVL are encoded...
primary pulmonary infections and can potentially become a rapidly necrotizingpneumonia with a potential to disseminate. The organism can be differentiated...
Onset of symptoms is often gradual, but in necrotizing staphylococcal or gram-negative bacillary pneumonias patients can be acutely ill. Cough, fever with...
usually last five to seven days. Complications may occasionally include pneumonia, inflammation of the brain, and bacterial skin infections. The disease...
agar. Ceyssens, K.; Devriese, L. A.; Maenhout, T. (1989-01-12). "NecrotizingPneumonia in Cats Associated with Infection by EF-4a Bacteria". Journal of...
hydrocarbon pneumonia. Hydrocarbon pneumonia is an acute hemorrhagic necrotizing disease that can develop within 24 h after the ingestion. Pneumonia may require...
inflammation is typically encountered. The granulomas can be necrotizing or non-necrotizing. Using a microscope and appropriate stains, organisms can be...
Pathogenic bacteria contribute to other globally important diseases, such as pneumonia, which can be caused by bacteria such as Staphylococcus, Streptococcus...
nervous system and eye causing endophthalmitis, nonhepatic abscesses, pneumonia, necrotizing fasciitis, and meningitis. One visual trait of these strains is...
pneumothorax occurs in people with AIDS, usually due to underlying pneumocystis pneumonia (PCP), as this condition is associated with prolonged air leakage. Bilateral...
can be carried for weeks or months. Adenovirus can cause severe necrotizingpneumonia in which all or part of a lung has increased translucency radiographically...
Lachance S, Leclerc JE, Lemaire-Lambert A (November 2020). "Necrotizing epiglottitis with necrotizing fasciitis in a child: A case report and review of literature"...
Chronic necrotizing aspergillosis and invasive aspergillosis are usually seen in immunocompromised people. Risk factors for chronic necrotizing aspergillosis...
mouth. The cat can also develop a purulent discharge from the eyes. Necrotizingpneumonia has also been observed. Estimates that 50% of human cases of cowpox...
hydrocarbon pneumonia. Hydrocarbon pneumonia is an acute hemorrhagic necrotizing disease that can develop within 24 h after the ingestion. Pneumonia may require...
people with acute pancreatitis, regardless of the type (interstitial or necrotizing) or disease severity (mild, moderately severe, or severe) In 30% of those...
this include streptococcal toxic shock syndrome (STSS), necrotizing fasciitis (NF), pneumonia, and bacteremia. In addition, infection of GAS may lead...
treat a number of bacterial infections. This includes pneumonia, strep throat, syphilis, necrotizing enterocolitis, diphtheria, gas gangrene, leptospirosis...
for many cases of pink eye, meningitis, bacterial pneumonia, endocarditis, erysipelas, and necrotizing fasciitis (the 'flesh-eating' bacterial infections)...
community-acquired pneumonia. A cohort analysis including over 11,000 neonates reported an association of H2 blocker use, and an increased incidence of necrotizing enterocolitis...
Global Information