Naphyrone, also known as O-2482 and naphthylpyrovalerone,[3] is a substituted cathinone drug derived from pyrovalerone that acts as a triple reuptake inhibitor,[4] producing stimulant effects and has been reported as a novel designer drug.[5] No safety or toxicity data is available on the drug.[6]
The drug has been marketed under the name NRG-1, although only a minority of samples of substances sold under this name have been found to actually contain naphyrone,[7][8][9] and even samples that proved to contain genuine β-naphyrone were in some cases also found to contain the 1-naphthyl isomer α-naphyrone in varying proportions, further confusing the reported effects profile.[10][11]
^"Schedules of Controlled Substances: Temporary Placement of 10 Synthetic Cathinones Into Schedule I". Archived from the original on 2015-04-14. Retrieved 2015-04-05.
^"Ustawa z dnia 15 kwietnia 2011 r. o zmianie ustawy o przeciwdziałaniu narkomanii ( Dz.U. 2011 nr 105 poz. 614 )". Internetowy System Aktów Prawnych. Archived from the original on June 27, 2012. Retrieved 17 June 2011.
^"Deadly New 'Legal' Drug Bound For Britain - Yahoo! News UK". Uk.news.yahoo.com. 2010-03-31. Archived from the original on April 5, 2010. Retrieved 2010-04-03.
^Meltzer PC, Butler D, Deschamps JR, Madras BK (February 2006). "1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors". Journal of Medicinal Chemistry. 49 (4): 1420–1432. doi:10.1021/jm050797a. PMC 2602954. PMID 16480278.
^Travis A (2010-04-01). "NRG-1 may be next legal high to face ban by ministers | Politics". The Guardian. Archived from the original on 2021-05-31. Retrieved 2010-04-03.
^Lavery M (2 April 2010). "New 50c legal drug 'is more evil' than any head shop high". The Herald. Archived from the original on 7 April 2010. Retrieved 2 April 2010.
^Brandt SD, Sumnall HR, Measham F, Cole J (July 2010). "Second generation mephedrone. The confusing case of NRG-1". BMJ. 341: c3564. doi:10.1136/bmj.c3564. PMID 20605894. S2CID 20354123.
^Brandt SD, Sumnall HR, Measham F, Cole J (August 2010). "Analyses of second-generation 'legal highs' in the UK: initial findings". Drug Testing and Analysis. 2 (8): 377–382. CiteSeerX 10.1.1.667.4728. doi:10.1002/dta.155. PMID 20687197.
^Wood DM, Davies S, Cummins A, Button J, Holt DW, Ramsey J, Dargan PI (December 2011). "Energy-1 ('NRG-1'): don't believe what the newspapers say about it being legal". Emergency Medicine Journal. 28 (12): 1068–1070. doi:10.1136/emj.07.2010.3184rep. PMC 3062281. PMID 22101594.
^Brandt SD, Wootton RC, De Paoli G, Freeman S (October 2010). "The naphyrone story: The alpha or beta-naphthyl isomer?". Drug Testing and Analysis. 2 (10): 496–502. CiteSeerX 10.1.1.669.1137. doi:10.1002/dta.185. PMID 20886463.
^De Paoli G, Maskell PD, Pounder DJ (February 2011). "Naphyrone: analytical profile of the new "legal high" substitute for mephedrone". Journal of Forensic and Legal Medicine. 18 (2): 93. doi:10.1016/j.jflm.2010.12.001. PMID 21315306.
Naphyrone, also known as O-2482 and naphthylpyrovalerone, is a substituted cathinone drug derived from pyrovalerone that acts as a triple reuptake inhibitor...
and naphyrone because its structure falls outside the generic definition and not enough evidence was yet available to justify a ban. Naphyrone analogues...
selection of some particularly notably abused DRIs: cocaine, ketamine, MDPV, naphyrone, and phencyclidine (PCP). Amphetamines, including amphetamine, methamphetamine...
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