Mouse models of Down syndrome information

Mouse models have frequently been used to study Down syndrome due to the close similarity in the genomes of mice and humans, and the prevalence of mice...

mouse model systems include mouse models of colorectal and intestinal cancer, mouse models of Down syndrome and mouse models of breast cancer metastasis...

Down syndrome or Down's syndrome, also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21...

eyes with down-slanting palpebral fissures, receding mandible and intellectual disability. A mouse model has been developed. This mouse model is characterized...

and has been shown to be down-regulated in trisomic neurospheres a mouse model of Down Syndrome, resulting in reduced numbers of neural progenitors and...

Bianca; Laviola, Giovanni (2008). "Mouse models of Rett syndrome: From behavioural phenotyping to preclinical evaluation of new therapeutic approaches". Behavioural...

2014). "A novel mouse model for Down syndrome that harbor a single copy of human artificial chromosome (HAC) carrying a limited number of genes from human...

abbreviations for Down syndrome cell adhesion molecule. In humans, DSCAM refers to a gene that encodes one of several protein isoforms. Down syndrome (DS), caused...

2012). "Altered tissue behavior of a non-aneurysmal descending thoracic aorta in the mouse model of Marfan syndrome". Cell and Tissue Research. 347 (1):...

Langdon Down, who is known for his description of Down syndrome. Down described approximately ten cases of youth he had known with unusual mental powers...

"The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome". J Physiol. 579 (Pt 1):...

Progeria is a specific type of progeroid syndrome, also known as Hutchinson–Gilford syndrome or Hutchinson–Gilford progeroid syndrome (HGPS). A single gene...

Muriel Davisson is an American geneticist who developed the Down syndrome mouse model Ts65Dn. In 1959 she graduated from Pemetic High School in Southwest...

"DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase". PLOS ONE...

TBX1 may be responsible for some of the symptoms in DiGeorge syndrome. Research in mouse models has shown that deletion of Tbx1 leads to several defects...

Engelbart build the first mouse prototype. They christened the device the mouse as early models had a cord attached to the rear part of the device which looked...

developed mouse model for Down syndrome, wounded by the Unabomber Eleazar Eskin (21st century), US computational biologist studying the genetic basis of human...

birth, other than Down syndrome (trisomy 21), are Edwards syndrome (trisomy 18) and Patau syndrome (trisomy 13). Complete trisomies of other chromosomes...

well as Fmr1 knockout mice; the latter are also used as animal models of Fragile X syndrome. The Norway rat has been used, for example, by Mady Hornig to...

by the appearance of premature aging. Werner syndrome is named after the German scientist Otto Werner. He identified the syndrome in four siblings observed...

mouse called Ts65Dn (segmental trisomy 16 mouse) as an excellent model for studying the Down syndrome. Ts65Dn mouse has genes on chromosomes 16 that are very...

progeroid syndrome does not necessarily imply progeria (Hutchinson–Gilford progeria syndrome), which is a specific type of progeroid syndrome. Progeroid...