DYRK1A information

DYRK1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VX3, 2WO6, 3ANQ, 3ANR, 4AZE, 4MQ1, 4MQ2, 4NCT, 4YLJ, 4YLK, 4YLL, 4YU2, 5AIK, 5A4Q, 5A4E, 5A3X, 5A4T, 5A54, 5A4L
Identifiers
Aliases	DYRK1A, DYRK, DYRK1, HP86, MNB, MNBH, MRD7, dual specificity tyrosine phosphorylation regulated kinase 1A
External IDs	OMIM: 600855; MGI: 1330299; HomoloGene: 55576; GeneCards: DYRK1A; OMA:DYRK1A - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	37,526,358 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	94,496,376 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; biceps brachii; ; Brodmann area 23; ; Skeletal muscle tissue of biceps brachii; ; bronchial epithelial cell; ; tibialis anterior muscle; ; middle temporal gyrus; ; germinal epithelium; ; visceral pleura; ; trabecular bone;
	Top expressed in
	zygote; ; cardiac muscle tissue of left ventricle; ; muscle of thigh; ; Gonadal ridge; ; secondary oocyte; ; tail of embryo; ; genital tubercle; ; extensor digitorum longus muscle; ; triceps surae; ; gastrocnemius muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; non-membrane spanning protein tyrosine kinase activity; kinase activity; protein self-association; protein serine/threonine kinase activity; protein binding; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; tau protein binding; ATP binding; identical protein binding; tau-protein kinase activity;
Cellular component	nuclear speck; nucleoplasm; nucleus; cytoplasm; cytoskeleton; axon; dendrite; ribonucleoprotein complex;
Biological process	positive regulation of protein deacetylation; phosphorylation; regulation of alternative mRNA splicing, via spliceosome; nervous system development; protein phosphorylation; negative regulation of mRNA splicing, via spliceosome; negative regulation of DNA damage response, signal transduction by p53 class mediator; peptidyl-serine phosphorylation; circadian rhythm; protein autophosphorylation; peptidyl-tyrosine phosphorylation; peptidyl-threonine phosphorylation; viral process; negative regulation of microtubule polymerization; positive regulation of RNA splicing; amyloid-beta formation; peptidyl-serine autophosphorylation; peptidyl-tyrosine autophosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	1859
	13548
	ENSG00000157540
	ENSMUSG00000022897
	Q13627
	Q61214
NM_001396; NM_101395; NM_130436; NM_130437; NM_130438;
	NM_001347721; NM_001347722; NM_001347723
	NM_001113389; NM_007890; NM_001347731
NP_001334650; NP_001334651; NP_001334652; NP_001387; NP_567824;
	NP_569120; NP_569122
NP_001106860; NP_001334660; NP_031916; NP_001389720; NP_001389721;
	NP_001389722
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity tyrosine-phosphorylation-regulated kinase 1A is an enzyme that in humans is encoded by the DYRK1A gene.^[5] Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region.^[6] These variants encode for at least five different isoforms.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000157540 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022897 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Guimera J, Pritchard M, Nadal M, Estivill X (Sep 1997). "Minibrain (MNBH) is a single copy gene mapping to human chromosome 21q22.2". Cytogenet Cell Genet. 77 (3–4): 182–4. doi:10.1159/000134571. PMID 9284911.
^ Bol SM, Moerland PD, Limou S, van Remmerden Y, Coulonges C, van Manen D, Herbeck JT, Fellay J, Sieberer M, Sietzema JG, van 't Slot R, Martinson J, Zagury JF, Schuitemaker H, van 't Wout AB (2011). "Genome-wide association study identifies single nucleotide polymorphism in DYRK1A associated with replication of HIV-1 in monocyte-derived macrophages". PLOS ONE. 6 (2): e17190. Bibcode:2011PLoSO...617190B. doi:10.1371/journal.pone.0017190. PMC 3045405. PMID 21364930.
^ "Entrez Gene: DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000157540 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022897 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9284911-5] Guimera J, Pritchard M, Nadal M, Estivill X (Sep 1997). "Minibrain (MNBH) is a single copy gene mapping to human chromosome 21q22.2". Cytogenet Cell Genet. 77 (3–4): 182–4. doi:10.1159/000134571. PMID 9284911.

[Bol_2011-6] Bol SM, Moerland PD, Limou S, van Remmerden Y, Coulonges C, van Manen D, Herbeck JT, Fellay J, Sieberer M, Sietzema JG, van 't Slot R, Martinson J, Zagury JF, Schuitemaker H, van 't Wout AB (2011). "Genome-wide association study identifies single nucleotide polymorphism in DYRK1A associated with replication of HIV-1 in monocyte-derived macrophages". PLOS ONE. 6 (2): e17190. Bibcode:2011PLoSO...617190B. doi:10.1371/journal.pone.0017190. PMC 3045405. PMID 21364930.

[entrez-7] "Entrez Gene: DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A".

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