Molecular glue refers to a class of chemical compounds or molecules that play a crucial role in binding and stabilizing protein-protein interactions in biological systems. These molecules act as "glue" by enhancing the affinity between proteins, ultimately influencing various cellular processes. Molecular glue compounds have gained significant attention in the fields of drug discovery, chemical biology, and fundamental research due to their potential to modulate protein interactions, and thus, impact various cellular pathways. They have unlocked avenues in medicine previously thought to be "undruggable".
Molecularglue refers to a class of chemical compounds or molecules that play a crucial role in binding and stabilizing protein-protein interactions in...
Adhesive, also known as glue, cement, mucilage, or paste, is any non-metallic substance applied to one or both surfaces of two separate items that binds...
(kolla), meaning 'glue'. These proteins form a molecular bond with the glued object.[citation needed] Conventionally, keratin glues, while made from animal...
able to execute their functions normally. In addition to serving as "molecularglue", CAMs play important roles in the cellular mechanisms of growth, contact...
poly(ethenyl ethanoate)), commonly known as wood glue, PVA glue, white glue, carpenter's glue, school glue, or Elmer's Glue in the US, is a widely available adhesive...
pathway. When TIR1/ AFB proteins bind to auxin, the auxin acts as a 'molecularglue' that allows these proteins to then bind to their targets (see below)...
Coagulation reinforces the platelet plug with fibrin threads that act as a "molecularglue". Platelets are a large factor in the hemostatic process. They allow...
increasing their stability and long-term reliability with a form of "molecularglue".[importance?] 21 May – The first industrial commercial production line...
Casein glue is also used in transformer manufacturing (specifically transformer board) due to its oil permeability. Elmer's Glue-All, Elmer's School Glue and...
increasing their stability and long-term reliability with a form of "molecularglue".[importance?] 21 May – The first industrial commercial production line...
reliability of perovskite solar cells was improved with a new kind of "molecularglue". As of 2021, the existing stability tests for solar panels and solar...
'jugular,' Biden briefed". Reuters. 8 May 2021. Retrieved 13 June 2021. ""Molecularglue" strengthens the weak point in perovskite solar cells". New Atlas. 10...
Molecular gastronomy is the scientific approach of cuisine from primarily the perspective of chemistry. The composition (molecular structure), properties...
paste, such as wheatpaste, which can be used as a thickening, stiffening or gluing agent. The principal non-food, industrial use of starch is as an adhesive...
weak acids. The name collagen comes from the Greek κόλλα (kólla), meaning "glue", and suffix -γέν, -gen, denoting "producing". Over 90% of the collagen in...
damage. When DNA damage occurs, SUMO protein has been shown to act as a molecularglue to facilitate the assembly of large protein complexes in repair foci...
act as adhesives. The term is sometimes used more loosely to describe a glue formed synthetically from biological monomers such as sugars, or to mean...
advances include the discovery that small molecules can function as “molecularglues” that promote protein–protein interactions, the co-discovery of mTOR...
models of molecular properties and behavior is referred to as molecular modeling, and their graphical depiction is referred to as molecular graphics....
hornets also use silk as a glue, as do spiders. Glues made from partially-hydrolysed keratin include hoof glue and horn glue. Abnormal growth of keratin...
interest. Notable recent discoveries include an inhibitor of mTORC1, a molecularglue between UBR7 and p53 that activates p53 tumor suppressor activity, a...
Hydrolysis of strigolactone, resulting in a free D-ring that serves as a molecularglue at the entrance of the receptor, mediating interaction with another...
silk soft and tacky. The glue balls are multifunctional – that is, their behavior depends on how quickly something touching a glue ball attempts to withdraw...
boron. Epoxies are also used as a structural glue. Materials like wood, and others that are 'low-tech' are glued with epoxy resin. Epoxies generally out-perform...
In molecular physics and chemistry, the van der Waals force is a distance-dependent interaction between atoms or molecules. Unlike ionic or covalent bonds...
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