Structure and sequence of the prototypic cyclotide kalata B1
Identifiers
Symbol
Cyclotide
Pfam
PF03784
InterPro
IPR005535
PROSITE
PDOC51052
SCOP2
1kal / SCOPe / SUPFAM
OPM superfamily
112
OPM protein
1nb1
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
In biochemistry, cyclotides are small, disulfide-rich peptides isolated from plants.[1] Typically containing 28-37 amino acids, they are characterized by their head-to-tail cyclised peptide backbone and the interlocking arrangement of their three disulfide bonds. These combined features have been termed the cyclic cystine knot (CCK) motif. To date, over 100 cyclotides have been isolated and characterized from species of the families Rubiaceae, Violaceae, and Cucurbitaceae. Cyclotides have also been identified in agriculturally important families such as the Fabaceae and Poaceae.[2][3][4]
^Craik DJ, Daly NL, Bond T, Waine C (December 1999). "Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif". Journal of Molecular Biology. 294 (5): 1327–36. doi:10.1006/jmbi.1999.3383. PMID 10600388.
^Poth AG, Colgrave ML, Lyons RE, Daly NL, Craik DJ (June 2011). "Discovery of an unusual biosynthetic origin for circular proteins in legumes". Proceedings of the National Academy of Sciences of the United States of America. 108 (25): 10127–32. Bibcode:2011PNAS..10810127P. doi:10.1073/pnas.1103660108. PMC 3121837. PMID 21593408.
^Nguyen GK, Zhang S, Nguyen NT, Nguyen PQ, Chiu MS, Hardjojo A, Tam JP (July 2011). "Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family". The Journal of Biological Chemistry. 286 (27): 24275–87. doi:10.1074/jbc.M111.229922. PMC 3129208. PMID 21596752.
^Nguyen GK, Lian Y, Pang EW, Nguyen PQ, Tran TD, Tam JP (February 2013). "Discovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants". The Journal of Biological Chemistry. 288 (5): 3370–80. doi:10.1074/jbc.M112.415356. PMC 3561556. PMID 23195955.
In biochemistry, cyclotides are small, disulfide-rich peptides isolated from plants. Typically containing 28-37 amino acids, they are characterized by...
and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family"...
the growth factor cystine knot (GFCK) and the cyclic cystine knot (CCK; cyclotide). Types include a) cyclic mobius, b) cyclic bracelet, c) acyclic inhibitor...
Jackson; David J. Craik (28 May 2019). "Butterfly Pea (Clitoria ternatea), a Cyclotide-Bearing Plant With Applications in Agriculture and Medicine". Frontiers...
kaempferol. V. tricolor is one of many viola plant species containing cyclotides. These small peptides have proven to be useful in drug development due...
individual residues on structure and activity in the prototypic cyclotide kalata B1. Cyclotides display a wide range of pharmaceutically important bioactivities...
of disturbed and cultivated areas. Viola arvensis was shown to contain cyclotides, a class of peptides found in plants. The peptide cycloviolacin O2 in...
countries.[citation needed] V. oderata contains the alkaloid violin, about 30 cyclotides, and triterpenoids, mostly as constituents of the essential oil.[citation...
Göransson, Ulf (2010-01-01). "Cyclotide proteins and precursors from the genus Gloeospermum: Filling a blank spot in the cyclotide map of Violaceae". Phytochemistry...
be infected with pathogenic Angiostrongylus cantonensis in 2009. Crude cyclotide extracts from both Oldenlandia affinis and Viola odorata plants showed...
extracts. Cliotides belong to a larger classification of peptides, the cyclotides. Preliminary studies show that cliotides display a variety of biochemical...
endangered species conservation and for somaclonal variation-enhanced cyclotide biosynthesis. Plant Cell Tiss Organ Cult 120, 179–190 (2015). doi.org/10...
W, et al. (August 2010). "Isolation and characterization of cytotoxic cyclotides from Viola tricolor". Peptides. 31 (8): 1434–40. doi:10.1016/j.peptides...
knot (ICK) common in spider and snail toxins Cyclic Cystine Knot, or cyclotide The growth factor cystine knot was first observed in the structure of...
found in naturally occurring peptides, including: cystine knot peptides, cyclotides or lasso-peptides such as microcin J25. The earliest reported synthesis...
Ninghua, Tan (2008). "Application of a TLC chemical method to detection of cyclotides in plants". Science Bulletin. 53 (11): 1671–1674. Bibcode:2008SciBu..53...
body pain in fever and malaria. Both hedyotide B1 and B2 belong to the cyclotide superfamily which was known to be an important part of plant innate defense...
bacteriostatic. Defensins Insect defensins Plant defensins, including Cyclotides and thionins Defensins are a type of antimicrobial peptide; and are an...
examples have been found in biological systems including: cystine knots, cyclotides or lasso-peptides such as microcin J25 which are proteins, and a variety...
rubbed with other herbs in butter to make a massage oil. Several unique cyclotides have been isolated from this species, that have cytotoxic properties and...
parturition in livestock. Researchers found that the plant contained novel cyclotides, but further research is needed on the efficacy of these extracts. Ojo...
during labour. Her work has also investigated the use of plant-derived cyclotides as well as modifications to the natural hormone oxytocin to serve as templates...
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