Global Information Lookup Global Information

Mesna information


Mesna
Clinical data
Pronunciation/ˈmɛznə/
AHFS/Drugs.comMonograph
Pregnancy
category
  • AU: B1
Routes of
administration
By mouth, intravenous
ATC code
  • R05CB05 (WHO) V03AF01 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
Bioavailability45–79% (by mouth)
MetabolismOxidised in circulation
Elimination half-life0.36–8.3 hours
Excretionkidney
Identifiers
IUPAC name
  • sodium 2-sulfanylethanesulfonate
CAS Number
  • 19767-45-4 ☒N
PubChem CID
  • 29769
ChemSpider
  • 27663 checkY
UNII
  • NR7O1405Q9
KEGG
  • D01459 checkY
ChEMBL
  • ChEMBL975 checkY
CompTox Dashboard (EPA)
  • DTXSID1020809 Edit this at Wikidata
ECHA InfoCard100.039.336 Edit this at Wikidata
Chemical and physical data
FormulaC2H5NaO3S2
Molar mass164.17 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • [Na+].[O-]S(=O)(=O)CCS
InChI
  • InChI=1S/C2H6O3S2.Na/c3-7(4,5)2-1-6;/h6H,1-2H2,(H,3,4,5);/q;+1/p-1 checkY
  • Key:XOGTZOOQQBDUSI-UHFFFAOYSA-M checkY
 ☒NcheckY (what is this?)  (verify)

Mesna, sold under the brand name Mesnex among others, is a medication used in those taking cyclophosphamide or ifosfamide to decrease the risk of bleeding from the bladder.[1] It is used either by mouth or injection into a vein.[1]

Common side effects include headache, vomiting, sleepiness, loss of appetite, cough, rash, and joint pain.[1] Serious side effects include allergic reactions.[1] Use during pregnancy appears to be safe for the baby but this use has not been well studied.[2] Mesna is an organosulfur compound.[3] It works by altering the breakdown products of cyclophosphamide and ifosfamide found in the urine making them less toxic.[1]

Mesna was approved for medical use in the United States in 1988.[1] It is on the World Health Organization's List of Essential Medicines.[4]

  1. ^ a b c d e f "Mesna". The American Society of Health-System Pharmacists. Archived from the original on 11 May 2017. Retrieved 8 December 2016.
  2. ^ "Mesna (Mesnex) Use During Pregnancy". www.drugs.com. Archived from the original on 11 May 2017. Retrieved 20 December 2016.
  3. ^ Patwardhan B, Chaguturu R (2016). Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting. Academic Press. p. 53. ISBN 9780128018224. Archived from the original on 2016-12-21.
  4. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

and 24 Related for: Mesna information

Request time (Page generated in 0.583 seconds.)

Mesna

Last Update:

Mesna, sold under the brand name Mesnex among others, is a medication used in those taking cyclophosphamide or ifosfamide to decrease the risk of bleeding...

Word Count : 665

Ifosfamide

Last Update:

The delivery is intravenous. Ifosfamide is often used in conjunction with mesna to avoid internal bleeding in the patient, in particular hemorrhagic cystitis...

Word Count : 665

Mesna Upper Secondary School

Last Update:

Mesna Upper Secondary School (Norwegian: Mesna videregående skole) is one of three public upper secondary schools in Lillehammer, Norway. It is located...

Word Count : 116

Reinhold Messner

Last Update:

considered for merging. › Reinhold Andreas Messner (German: [ˈʁaɪnhɔlt ˈmɛsnɐ]; born 17 September 1944) is an Italian climber, explorer, and author from...

Word Count : 5528

Sodium methanethiolate

Last Update:

Sodium methanethiolate or sodium thiomethoxide (CH3SNa, MeSNa) is the sodium conjugate base of methanethiol. This compound is commercially available as...

Word Count : 68

Moskona language

Last Update:

Timur District (in Sumuy, Mesna, and Igomu villages), Mardey District, Masyeta District, Jagiro District, Moyeba District, and Mesna District. Meninggo at...

Word Count : 106

Methanethiol

Last Update:

(PhO−) and releasing MeSH. Due to alkalinity, MeSH is readily deprotonated (MeSNa), and the formed MeS− ion is also a strong nucleophile, reacting further...

Word Count : 1247

Acetylcysteine

Last Update:

been used for cyclophosphamide-induced haemorrhagic cystitis, although mesna is generally preferred due to the ability of acetylcysteine to diminish...

Word Count : 5251

Sodium salts

Last Update:

sulfapyridine, sulfaquinoxaline, sulfathiazole, sulfazecin, thiamylal and mesna. The disodium salt of cromolyn is also used as drug. Most of these salts...

Word Count : 314

Syrmia

Last Update:

Srem u narodnooslobodilačkom ratu i socijalističkoj revoluciji. Šimanovci, Mesna zajednica-Mesni odbor SUB NOR-a. Đorđe Cvejić; Jovan Babović; Miodrag Živković...

Word Count : 2797

Uterine myomectomy

Last Update:

less evidence supporting the usefulness chemical dissection (such as with mesna), vaginal insertion of dinoprostone, a gelatin–thrombin matrix, tranexamic...

Word Count : 1038

Osteosarcoma

Last Update:

leucovorin rescue, intra-arterial cisplatin, adriamycin, ifosfamide with mesna, BCD (bleomycin, cyclophosphamide, dactinomycin), etoposide, and muramyl...

Word Count : 3791

Cyclophosphamide

Last Update:

minimized with adequate fluid intake, avoidance of nighttime dosage and mesna (sodium 2-mercaptoethane sulfonate), a sulfhydryl donor which binds and...

Word Count : 3988

Prostitution in Finland

Last Update:

that they ignore the disadvantaged status of foreign prostitutes. Marte Mesna argues that deporting foreigners where they are suspected of coming into...

Word Count : 4090

List of Belgrade neighbourhoods and suburbs

Last Update:

are officially divided into local communities (Serbian: месна заједница / mesna zajednica). These are arbitrary administrative units which on occasion correspond...

Word Count : 350

Hemorrhagic cystitis

Last Update:

athletic training, particularly in runners.[citation needed] Unfortunately mesna is ineffective as a treatment once hemorrhagic cystitis has developed. Although...

Word Count : 696

Lillehammer

Last Update:

through which the historical highway from Oslo to Trondheim passes. The Mesna river has provided the basis for several small industries through the years...

Word Count : 3312

Dacarbazine

Last Update:

1093/annonc/mdh465. PMID 15550585. Elias A, Ryan L, Aisner J, Antman KH (April 1990). "Mesna, doxorubicin, ifosfamide, dacarbazine (MAID) regimen for adults with advanced...

Word Count : 1065

Oppland

Last Update:

(Quiekne) Land Lesja (Læssø) Lesjaskog Lillehammer Lom Lomen (Røn, Røen) Lunner Mesna Nes (Brandbu) Nord-Aurdal Nord-Fron Nordberg Nordre Etnedal Nordre Land...

Word Count : 831

Urine test strip

Last Update:

medicines that contain sulfhydryl groups, such as mercaptoethane sulphonate Na (Mesna) and captopril and L-DOPA can give atypical colouring. A false negative...

Word Count : 6376

Chemotherapy regimen

Last Update:

bleomycin non-Hodgkin lymphoma MAID mesna, doxorubicin, ifosfamide, dacarbazine soft-tissue sarcoma MINE mesna, ifosfamide, novantrone, etoposide Non-Hodgkin...

Word Count : 627

Thor Lillehovde

Last Update:

1988 and been a board member of Brumunddal IL since 2007. He has chaired Mesna Kraftselskap from 1996 to 2002 and been a board member of Hamarregionen...

Word Count : 220

Haakon Thallaug

Last Update:

from 1954 and the council of the Nansen Academy since 1966. He chaired Mesna Bruk from 1955, Lillehammer Bryggeri from 1955 to 1967 (board member since...

Word Count : 247

New Belgrade

Last Update:

Serbia, New Belgrade is further divided into local communities (Serbian: mesna zajednica). Apart from Bežanija and Staro Sajmište, no other neighbourhoods...

Word Count : 10831

PDF Search Engine © AllGlobal.net