Mefloquine, sold under the brand name Lariam among others, is a medication used to prevent or treat malaria.[4] When used for prevention it is typically started before potential exposure and continued for several weeks after potential exposure.[4] It can be used to treat mild or moderate malaria but is not recommended for severe malaria.[4] It is taken by mouth.[4]
Common side effects include vomiting, diarrhea, headaches, sleep disorders, and a rash.[4] Serious side effects include potentially long-term mental health problems such as depression, hallucinations, and anxiety and neurological side effects such as poor balance, seizures, and ringing in the ears.[4] It is therefore not recommended in people with a history of mental health problems or epilepsy.[4] It appears to be safe during pregnancy and breastfeeding.[1]
Mefloquine was developed by the United States Army in the 1970s and came into use in the mid-1980s.[5][6][7] It is on the World Health Organization's List of Essential Medicines.[8][9] It is available as a generic medication.[4]
^ ab"Mefloquine (Lariam) Use During Pregnancy". Drugs.com. Retrieved 31 March 2019.
^"Lariam 250 mg tablets - Summary of Product Characteristics (SmPC)". (emc). 3 April 2019. Retrieved 8 September 2020.
^"Lariam brand of mefloquine hydrochloride tablets". DailyMed. Retrieved 9 October 2022.
^ abcdefgh"Mefloquine Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 2015-12-08. Retrieved 27 Nov 2015.
^Croft AM (April 2007). "A lesson learnt: the rise and fall of Lariam and Halfan". Journal of the Royal Society of Medicine. 100 (4): 170–174. doi:10.1177/014107680710011411. PMC 1847738. PMID 17404338.
^Ravina E (2011). The evolution of drug discovery : from traditional medicines to modern drugs (1. Aufl. ed.). Weinheim: Wiley-VCH. p. 136. ISBN 9783527326693.
^Farrar J, Hotez PJ, Junghanss T (2013). Manson's tropical diseases (23rd ed.). Oxford: Elsevier/Saunders. p. 569. ISBN 9780702053061.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
Mefloquine, sold under the brand name Lariam among others, is a medication used to prevent or treat malaria. When used for prevention it is typically started...
is a medication with several uses. It is related to chloroquine and mefloquine. Although formerly available from compounding pharmacies, as of August...
where there is known to be a high level of resistance to chloroquine, mefloquine, and sulfa drug combinations with pyrimethamine. Quinine is also used...
still sensitive, however many malaria parasite strains are now resistant. Mefloquine (Lariam), doxycycline, or the combination of atovaquone and proguanil...
medications that includes artemisinin. The second medication may be either mefloquine, lumefantrine, or sulfadoxine/pyrimethamine. Quinine, along with doxycycline...
In July 2013, the FDA issued a boxed warning for the antimalarial drug mefloquine, noting the drug's adverse neuropsychiatric side effects, and emphasizing...
Often it is used as part of combination therapy, such as artesunate plus mefloquine. It is not used for the prevention of malaria. Artesunate can be given...
seeking a new trial in civilian court due to possible side effects of mefloquine, an anti-malaria drug Bales claims to have been taking at the time of...
of a PML patient being successfully treated with the antimalarial drug mefloquine with activity against the JC virus. The patient cleared the virus and...
Neuropsychiatric quinism is a chronic encephalopathy due to intoxication by mefloquine, quinacrine, chloroquine. It is associated with brain dysfunction and...
the cause of Stromae's health issues were an anti-malaria drug called mefloquine, he had used ahead of and during his tour in Africa in 2015. The drug...
Sarajevo. In 1997, Lloyd went to India where she took the anti-malaria drug mefloquine, which is contraindicated for people with mental disorders. Lloyd became...
derivatives as AL-1095, diphemethoxidine, SCH-5472 and D2PM), and even mefloquine, 2-benzylpiperidine, rimiterol, enpiroline and DMBMPP, can also be considered...
as effective as artesunate plus mefloquine at treating malaria (moderate quality evidence). Artesunate plus mefloquine probably causes more nausea, vomiting...
artesunate, or mefloquine. A Cochrane review found tentative evidence that when used alone, metrifonate was as effective as praziquantel. Mefloquine, which has...
north-western border of Thailand during five years of extensive use of artesunate-mefloquine". Transactions of the Royal Society of Tropical Medicine and Hygiene....
abnormal heart rhythms (ventricular arrhythmias) if used concurrently. Mefloquine and other drugs known to lower the seizure threshold (co-administration...
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