Malignant histiocytosis is a rare hereditary disease found in the Bernese Mountain Dog and humans, characterized by histiocytic infiltration of the lungs and lymph nodes. The liver, spleen, and central nervous system can also be affected. Histiocytes are a component of the immune system that proliferate abnormally in this disease. In addition to its importance in veterinary medicine, the condition is also important in human pathology.[2]
^James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
Malignanthistiocytosis is a rare hereditary disease found in the Bernese Mountain Dog and humans, characterized by histiocytic infiltration of the lungs...
birth to age 15. Histiocytosis (and malignanthistiocytosis) are both important in veterinary as well as human pathology. Histiocytosis is a rare disease...
all tumours in the breed. Other histiocytosis conditions such as systemic histiocytosis and cutaneous histiocytosis are also more prevalent in the breed...
cells) 2. Reactive histiocytosis (immunohistochemical features show that interstitial/dermal DCs are involved) 2.a. Cutaneous histiocytosis (CH) 2.b. Systemic...
legs; while in men, on the back. Melanoma is frequently referred to as malignant melanoma. However, the medical community stresses that there is no such...
sarcoma (LCS) is a rare form of malignanthistiocytosis. It should not be confused with Langerhans cell histiocytosis, which is cytologically benign....
common causes of FUO. Although most neoplasms can present with fever, malignant lymphoma is by far the most common diagnosis of FUO among the neoplasms...
related to proliferation or abnormality of these cells, such as malignanthistiocytosis, histiocytic lymphoma, and Gaucher's disease. Anti-CD68 monoclonal...
(class II), and malignanthistiocytosis (class III). They provided the criteria to definitively diagnose Langerhans cell histiocytosis. Tebbi, Cameron...
young dogs (<4 years), and often regresses without treatment. Malignanthistiocytosis (histiocytic sarcoma) is an aggressive cancer found primarily in...
Interdigitating dendritic cell sarcoma is a form of malignanthistiocytosis affecting dendritic cells. It can present in the spleen. It can also present...
in viral infections, skin diseases, and nonspecific reactions. Sinus histiocytosis: It is seen in lymph nodes draining limbs, inflammatory lesions, and...
pathological study on granulomatous meningoencephalomyelitis and central malignanthistiocytosis in dogs". J Vet Med Sci. 65 (12): 1319–24. doi:10.1292/jvms.65...
and painful obstructions (so-called "malignant by location", despite being a benign growth histologically). Malignant transformation of lipomas into liposarcomas...
A. H. T. Robb-Smith, described the clinical manifestations of malignanthistiocytosis. When WWII began, Scott had just obtained an appointment as consultant...
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