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zf-MIZ
Identifiers
Symbol
zf-MIZ
Pfam
PF02891
Pfam clan
CL0229
InterPro
IPR004181
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
In molecular biology the MIZ-type zinc finger domain is a zinc finger-containing protein with homology to the yeast protein, Nfi-1. Miz1 is a sequence specific DNA binding protein that can function as a positive-acting transcription factor. Miz1 binds to the homeobox protein Msx2, enhancing the specific DNA-binding ability of Msx2.[1] Other proteins containing this domain include the human pias family (protein inhibitor of activated STAT protein). The name MIZ is derived from Msx-interacting-zinc finger. The crystal structure of S. cerevisiae sumo e3 ligase siz1 containing this domain has been solved.
^Wu L, Wu H, Ma L, Sangiorgi F, Wu N, Bell JR, Lyons GE, Maxson R (July 1997). "Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA". Mech. Dev. 65 (1–2): 3–17. doi:10.1016/S0925-4773(97)00032-4. PMID 9256341. S2CID 11835268.
In molecular biology the MIZ-type zincfinger domain is a zincfinger-containing protein with homology to the yeast protein, Nfi-1. Miz1 is a sequence...
Peukert K, Eilers M, Hänel F (1997). "Association of Myc with the Zinc-finger Protein Miz-1 Defines a Novel Pathway for Gene Regulation by Myc". C-Myc in...
ZincfingerMIZ domain-containing protein 1 is a protein that in humans is encoded by the ZMIZ1 gene. ZMIZ1 has been shown to interact with Androgen receptor...
ZincfingerMIZ domain-containing protein 2 is a protein that in humans is encoded by the ZMIZ2 gene. GRCh38: Ensembl release 89: ENSG00000122515 – Ensembl...
ZMIZ2: zincfingerMIZ domain-containing protein 2 ZNF277P: zincfinger protein 277 ZRF1: DnaJ heat shock protein family (Hsp40) member C2 ZSCAN21: zinc finger...
transcriptional repressor. By binding Miz-1 transcription factor and displacing the p300 co-activator, it inhibits expression of Miz-1 target genes. In addition...
Wu N, Bell JR, Lyons GE, Maxson R (September 1997). "Miz1, a novel zincfinger transcription factor that interacts with Msx2 and enhances its affinity...
"Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc". The Biochemical Journal. 370 (Pt 1): 291–8. doi:10.1042/BJ20021679...
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