MAP2K7 information

MAP2K7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DYL, 3WZU, 4UX9, 5B2K, 5B2L, 5B2M
Identifiers
Aliases	MAP2K7, JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4, mitogen-activated protein kinase kinase 7
External IDs	OMIM: 603014 MGI: 1346871 HomoloGene: 56548 GeneCards: MAP2K7
Gene location (Human)
Chr.	Chromosome 19 (human)
End	7,914,478 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	4,297,897 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; nipple; ; cardia; ; body of tongue; ; gastric mucosa; ; vena cava; ; skin of abdomen; ; canal of the cervix; ; subthalamic nucleus; ; inferior ganglion of vagus nerve;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; median eminence; ; habenula; ; arcuate nucleus; ; lateral geniculate nucleus; ; paraventricular nucleus of hypothalamus; ; dorsomedial hypothalamic nucleus; ; lateral hypothalamus; ; superior colliculus;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; nucleotide binding; protein tyrosine kinase activity; protein kinase binding; protein kinase activity; magnesium ion binding; transferase activity; kinase activity; ATP binding; enzyme binding; protein phosphatase binding; protein binding; MAP kinase kinase activity; protein serine/threonine kinase activity; JUN kinase kinase activity;
Cellular component	nucleus; cytoplasm; cytosol;
Biological process	response to UV; signal transduction; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; positive regulation of telomere capping; apoptotic process; response to osmotic stress; peptidyl-tyrosine phosphorylation; response to tumor necrosis factor; protein phosphorylation; response to heat; phosphorylation; stress-activated MAPK cascade; regulation of mitotic cell cycle; regulation of apoptotic process; stress-activated protein kinase signaling cascade; activation of protein kinase activity; positive regulation of transcription, DNA-templated; positive regulation of ERK1 and ERK2 cascade; JNK cascade; Fc-epsilon receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5609
	26400
	ENSG00000076984
	ENSMUSG00000002948
	O14733
	Q8CE90
	NM_001297555; NM_001297556; NM_145185
NM_001042557; NM_001164172; NM_001291777; NM_001291778; NM_001291783;
	NM_011944
	NP_001284484; NP_001284485; NP_660186
NP_001036022; NP_001157644; NP_001278706; NP_001278707; NP_001278712;
	NP_036074
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity mitogen-activated protein kinase kinase 7, also known as MAP kinase kinase 7 or MKK7, is an enzyme that in humans is encoded by the MAP2K7 gene.^[5] This protein is a member of the mitogen-activated protein kinase kinase family. The MKK7 protein exists as six different isoforms with three possible N-termini (α, β, and γ isoforms) and two possible C-termini (1 and 2 isoforms).^[6]

MKK7 is involved in signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK.^{[citation needed]}

MKK7 is ubiquitously expressed in all tissue. However, it displays a higher level of expression in skeletal muscle.^[7] Multiple alternatively spliced transcript variants encoding distinct isoforms have been found.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000076984 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002948 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: MAP2K7 mitogen-activated protein kinase kinase 7".
^ Tournier C, Whitmarsh AJ, Cavanagh J, et al. (February 1999). "The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases". Molecular and Cellular Biology. 19 (2): 1569–81. doi:10.1128/mcb.19.2.1569. PMC 116085. PMID 9891090.
^ Foltz IN, Gerl RE, Wieler JS, et al. (April 1998). "Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli". The Journal of Biological Chemistry. 273 (15): 9344–51. doi:10.1074/jbc.273.15.9344. PMID 9535930.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000076984 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002948 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MAP2K7 mitogen-activated protein kinase kinase 7".

[Tournier_1999-6] Tournier C, Whitmarsh AJ, Cavanagh J, et al. (February 1999). "The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases". Molecular and Cellular Biology. 19 (2): 1569–81. doi:10.1128/mcb.19.2.1569. PMC 116085. PMID 9891090.

[7] Foltz IN, Gerl RE, Wieler JS, et al. (April 1998). "Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli". The Journal of Biological Chemistry. 273 (15): 9344–51. doi:10.1074/jbc.273.15.9344. PMID 9535930.

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