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Leukotriene A4 information


Leukotriene A4
Names
Preferred IUPAC name
4-{(2S,3S)-3-[(1E,3E,5Z,8Z)-Tetradeca-1,3,5,8-tetraen-1-yl]oxiran-2-yl}butanoic acid
Identifiers
CAS Number
  • 72059-45-1 checkY
3D model (JSmol)
  • Interactive image
Abbreviations LTA4
ChEBI
  • CHEBI:15651 ☒N
ChemSpider
  • 4444074 ☒N
IUPHAR/BPS
  • 5214
KEGG
  • C00909 ☒N
MeSH D017572
PubChem CID
  • 5280383
UNII
  • 7Y7MPZ6563 checkY
CompTox Dashboard (EPA)
  • DTXSID40903945 Edit this at Wikidata
InChI
  • InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 ☒N
    Key: UFPQIRYSPUYQHK-WAQVJNLQSA-N ☒N
  • InChI=1/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1
    Key: UFPQIRYSPUYQHK-WAQVJNLQBZ
SMILES
  • CCCCC/C=C\C/C=C\C=C\C=C\[C@H]1[C@@H](O1)CCCC(=O)O
Properties
Chemical formula
C20H30O3
Molar mass 318.457 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references

Leukotriene A4 (LTA4) is a leukotriene, and is the precursor for the productions of leukotriene B4 (LTB4) and leukotriene C4 (LTC4).

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Leukotriene

Last Update:

acid (5-HETE). The enzyme 5-LO acts again on 5-HETE to convert it into leukotriene A4 (LTA4), an unstable epoxide. 5-HETE can be further metabolized to 5-oxo-ETE...

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Leukotriene A4

Last Update:

Leukotriene A4 (LTA4) is a leukotriene, and is the precursor for the productions of leukotriene B4 (LTB4) and leukotriene C4 (LTC4). Following the biosynthesis...

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Leukotriene A4 synthase

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Leukotriene A4 synthase may refer to: Arachidonate 5-lipoxygenase, an enzyme Arachidonate 12-lipoxygenase, an enzyme This set index page lists enzyme articles...

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Antileukotriene

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antileukotriene, also known as leukotriene modifier and leukotriene receptor antagonist, is a medication which functions as a leukotriene-related enzyme inhibitor...

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Leukotriene B4

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lysosomal enzymes by these cells. It is synthesized by leukotriene-A4 hydrolase from leukotriene A4. A study at the University of California, San Diego School...

Word Count : 238

Eicosanoid

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act convert 5-HPETE to leukotriene A4 (LTA4). LTA4 is then metabolized either to LTB4 by leukotriene A4 hydrolase or leukotriene C4 (LTC4) by either LTC4...

Word Count : 9517

Montelukast

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Montelukast is in the leukotriene receptor antagonist family of medications. It works by blocking the action of leukotriene D4 in the lungs resulting...

Word Count : 2283

Epoxide hydrolase

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related isozymes. Other enzymes with epoxide hydrolase activity include leukotriene A4 hydrolase, Cholesterol-5,6-oxide hydrolase, MEST (gene) (Peg1/MEST)...

Word Count : 2208

Linoleic acid

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elongation and unsaturation. AA is the precursor to some prostaglandins, leukotrienes (LTA, LTB, LTC), thromboxane (TXA) and the N-acylethanolamine (NAE)...

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Arachidonic acid

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which in turn converts to various leukotrienes (i.e., leukotriene B4, leukotriene C4, leukotriene D4, and leukotriene E4) as well as to 5-hydroxyeicosatetraenoic...

Word Count : 1878

Leukotriene C4 synthase

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converts leukotriene A4 and glutathione to create leukotriene C4. This is a member of MAPEG family of transmembrane proteins. A trimer of Leukotriene C4 synthase...

Word Count : 889

Ubenimex

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inhibitor. It is an inhibitor of arginyl aminopeptidase (aminopeptidase B), leukotriene A4 hydrolase (a zinc metalloprotease that displays both epoxide hydrolase...

Word Count : 491

Leukotriene E4

Last Update:

Leukotriene E4 (LTE4) is a cysteinyl leukotriene involved in inflammation. It is known to be produced by several types of white blood cells, including...

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Curcumin

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LTA4HTooltip Leukotriene A4 hydrolase Acebilustat Captopril DG-051 Fosinoprilat JNJ-26993135 SA-6541 SC-57461A Ubenimex (bestatin) LTB4HTooltip Leukotriene B4 ω-hydroxylase...

Word Count : 2425

Leukotriene D4

Last Update:

Leukotriene D4 (LTD4) is one of the leukotrienes. Its main function in the body is to induce the contraction of smooth muscle, resulting in bronchoconstriction...

Word Count : 80

Azelastine

Last Update:

LTA4HTooltip Leukotriene A4 hydrolase Acebilustat Captopril DG-051 Fosinoprilat JNJ-26993135 SA-6541 SC-57461A Ubenimex (bestatin) LTB4HTooltip Leukotriene B4 ω-hydroxylase...

Word Count : 1244

Captopril

Last Update:

LTA4HTooltip Leukotriene A4 hydrolase Acebilustat Captopril DG-051 Fosinoprilat JNJ-26993135 SA-6541 SC-57461A Ubenimex (bestatin) LTB4HTooltip Leukotriene B4 ω-hydroxylase...

Word Count : 2242

Leukotriene C4

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Leukotriene C4 (LTC4) is a leukotriene. LTC4 has been extensively studied in the context of allergy and asthma. In cells of myeloid origin such as mast...

Word Count : 563

Zafirlukast

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Zafirlukast is an orally administered leukotriene receptor antagonist (LTRA) used for the chronic treatment of asthma. While zafirlukast is generally...

Word Count : 2524

CYP4F2

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the sequential actions of 5-LOX, 5-LOX activating protein (FLAP), and leukotriene A4 hydrolase (LTA4H). LTB4 is produced by activated innate immune cells...

Word Count : 8922

Lipoxygenase

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leukotriene A4 (LTA4) which may then be converted to leukotriene B4 (LTB4) or leukotriene C4 (LTC4) (LTC4 may be further metabolized to leukotriene D4...

Word Count : 3886

Leukotriene receptor

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proteins: Leukotriene B4 receptors (BLTRs) – bind to and are activated by LTB4: BLT1 (Leukotriene B4 receptor 1) – LTB4R BLT2 (Leukotriene B4 receptor...

Word Count : 156

Diglyceride

Last Update:

Diacylglycerol Arachidonic acid 5-HPETE (arachidonic acid 5-hydroperoxide) Leukotriene A4 See also Receptor/signaling modulators Prostanoid signaling modulators...

Word Count : 925

Zileuton

Last Update:

Zyflo) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, used for the maintenance treatment...

Word Count : 1248

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