acid (5-HETE). The enzyme 5-LO acts again on 5-HETE to convert it into leukotrieneA4 (LTA4), an unstable epoxide. 5-HETE can be further metabolized to 5-oxo-ETE...
LeukotrieneA4 (LTA4) is a leukotriene, and is the precursor for the productions of leukotriene B4 (LTB4) and leukotriene C4 (LTC4). Following the biosynthesis...
LeukotrieneA4 synthase may refer to: Arachidonate 5-lipoxygenase, an enzyme Arachidonate 12-lipoxygenase, an enzyme This set index page lists enzyme articles...
antileukotriene, also known as leukotriene modifier and leukotriene receptor antagonist, is a medication which functions as a leukotriene-related enzyme inhibitor...
lysosomal enzymes by these cells. It is synthesized by leukotriene-A4 hydrolase from leukotrieneA4. A study at the University of California, San Diego School...
act convert 5-HPETE to leukotrieneA4 (LTA4). LTA4 is then metabolized either to LTB4 by leukotrieneA4 hydrolase or leukotriene C4 (LTC4) by either LTC4...
Montelukast is in the leukotriene receptor antagonist family of medications. It works by blocking the action of leukotriene D4 in the lungs resulting...
related isozymes. Other enzymes with epoxide hydrolase activity include leukotrieneA4 hydrolase, Cholesterol-5,6-oxide hydrolase, MEST (gene) (Peg1/MEST)...
elongation and unsaturation. AA is the precursor to some prostaglandins, leukotrienes (LTA, LTB, LTC), thromboxane (TXA) and the N-acylethanolamine (NAE)...
which in turn converts to various leukotrienes (i.e., leukotriene B4, leukotriene C4, leukotriene D4, and leukotriene E4) as well as to 5-hydroxyeicosatetraenoic...
converts leukotrieneA4 and glutathione to create leukotriene C4. This is a member of MAPEG family of transmembrane proteins. A trimer of Leukotriene C4 synthase...
inhibitor. It is an inhibitor of arginyl aminopeptidase (aminopeptidase B), leukotrieneA4 hydrolase (a zinc metalloprotease that displays both epoxide hydrolase...
Leukotriene E4 (LTE4) is a cysteinyl leukotriene involved in inflammation. It is known to be produced by several types of white blood cells, including...
Leukotriene D4 (LTD4) is one of the leukotrienes. Its main function in the body is to induce the contraction of smooth muscle, resulting in bronchoconstriction...
Leukotriene C4 (LTC4) is a leukotriene. LTC4 has been extensively studied in the context of allergy and asthma. In cells of myeloid origin such as mast...
Zafirlukast is an orally administered leukotriene receptor antagonist (LTRA) used for the chronic treatment of asthma. While zafirlukast is generally...
the sequential actions of 5-LOX, 5-LOX activating protein (FLAP), and leukotrieneA4 hydrolase (LTA4H). LTB4 is produced by activated innate immune cells...
leukotrieneA4 (LTA4) which may then be converted to leukotriene B4 (LTB4) or leukotriene C4 (LTC4) (LTC4 may be further metabolized to leukotriene D4...
Zyflo) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, used for the maintenance treatment...