Oxytocinase information

Oxytocinase is a type of enzyme that metabolizes the endogenous neuropeptide, oxytocin.^[1] The most well-characterized oxytocinase is leucyl/cystinyl aminopeptidase,^[1]^[2] which is also an enkephalinase. Other oxytocinases are also known.^[1]^[3] During pregnancy, oxytocinase plays a role in balancing concentration of oxytocin by degrading the oxytocin produced by the fetus, as production of oxytocin increases with growth of fetus.^[2] One study found that concentration level of oxytocinase increased progressively with gestational age until labor, which indicates that pregnancy development can be statistically evaluated by comparing oxytocinase levels.^[4]

^ ^a ^b ^c Tsujimoto M, Hattori A (2005). "The oxytocinase subfamily of M1 aminopeptidases". Biochim. Biophys. Acta. 1751 (1): 9–18. doi:10.1016/j.bbapap.2004.09.011. PMID 16054015.
^ ^a ^b Nomura S, Ito T, Yamamoto E, Sumigama S, Iwase A, Okada M, Shibata K, Ando H, Ino K, Kikkawa F, Mizutani S (2005). "Gene regulation and physiological function of placental leucine aminopeptidase/oxytocinase during pregnancy". Biochim. Biophys. Acta. 1751 (1): 19–25. doi:10.1016/j.bbapap.2005.04.006. PMID 15894523.
^ Mizutani S, Yokosawa H, Tomoda Y (1992). "Degradation of oxytocin by the human placenta: effect of selective inhibitors". Acta Endocrinol. 127 (1): 76–80. doi:10.1530/acta.0.1270076. PMID 1355623.
^ Klimek, Marek (August 2005). "Comparative analysis of ACTH and oxytocinase plasma concentration during pregnancy". Neuro Endocrinology Letters. 26 (4): 337–341. ISSN 0172-780X. PMID 16136013.

[pmid16054015-1] Tsujimoto M, Hattori A (2005). "The oxytocinase subfamily of M1 aminopeptidases". Biochim. Biophys. Acta. 1751 (1): 9–18. doi:10.1016/j.bbapap.2004.09.011. PMID 16054015.

[pmid15894523-2] Nomura S, Ito T, Yamamoto E, Sumigama S, Iwase A, Okada M, Shibata K, Ando H, Ino K, Kikkawa F, Mizutani S (2005). "Gene regulation and physiological function of placental leucine aminopeptidase/oxytocinase during pregnancy". Biochim. Biophys. Acta. 1751 (1): 19–25. doi:10.1016/j.bbapap.2005.04.006. PMID 15894523.

[pmid1355623-3] Mizutani S, Yokosawa H, Tomoda Y (1992). "Degradation of oxytocin by the human placenta: effect of selective inhibitors". Acta Endocrinol. 127 (1): 76–80. doi:10.1530/acta.0.1270076. PMID 1355623.

[4] Klimek, Marek (August 2005). "Comparative analysis of ACTH and oxytocinase plasma concentration during pregnancy". Neuro Endocrinology Letters. 26 (4): 337–341. ISSN 0172-780X. PMID 16136013.

Oxytocinase information

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Oxytocinase

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Enkephalinase

ERAP2

ERAP1