Enkephalinases are enzymes that degrade endogenous enkephalin opioid peptides. They include:
Aminopeptidase N (APN)[1]
Neutral endopeptidase (NEP)[1]
Dipeptidyl peptidase 3 (DPP3)[1]
Carboxypeptidase A6 (CPA6)[2]
Leucyl/cystinyl aminopeptidase (LNPEP)
Angiotensin-converting enzyme (ACE)[3]
^ abcThanawala V, Kadam VJ, Ghosh R (October 2008). "Enkephalinase inhibitors: potential agents for the management of pain". Current Drug Targets. 9 (10): 887–94. doi:10.2174/138945008785909356. PMID 18855623. Archived from the original on 2013-04-14.
^Lyons PJ, Callaway MB, Fricker LD (March 2008). "Characterization of carboxypeptidase A6, an extracellular matrix peptidase". The Journal of Biological Chemistry. 283 (11): 7054–63. doi:10.1074/jbc.M707680200. PMID 18178555.
^Benuck M, Berg MJ, Marks N (1982). "Separate metabolic pathways for Leu-enkephalin and Met-enkephalin-Arg(6)-Phe(7) degradation by rat striatal synaptosomal membranes". Neurochemistry International. 4 (5): 389–96. doi:10.1016/0197-0186(82)90081-X. PMID 20487892. S2CID 23138078.
Enkephalinases are enzymes that degrade endogenous enkephalin opioid peptides. They include: Aminopeptidase N (APN) Neutral endopeptidase (NEP) Dipeptidyl...
An enkephalinase inhibitor is a type of enzyme inhibitor which inhibits one or more members of the enkephalinase class of enzymes that break down the...
acetorphan, is an antidiarrheal medication which acts as a peripheral enkephalinase inhibitor. Unlike other opioid medications used to treat diarrhea, which...
M, et al. (2000). "Thiorphan, an inhibitor of neutral endopeptidase/enkephalinase (CD10/CALLA) enhances cell proliferation in bone marrow cultures of...
synthetic opioid peptide which is a potent and competitive inhibitor of the enkephalinase class of enzymes which break down the endogenous enkephalin peptides...
an enkephalinase inhibitor. Spillantini MG, Geppetti P, Fanciullacci M, Michelacci S, Lecomte JM, Sicuteri F (June 1986). "In vivo 'enkephalinase' inhibition...
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