For compounds containing the element lead, see Lead compounds.
A lead compound (/ˈliːd/, i.e. a "leading" compound, not to be confused with various compounds of the metallic element lead) in drug discovery is a chemical compound that has pharmacological or biological activity likely to be therapeutically useful, but may nevertheless have suboptimal structure that requires modification to fit better to the target; lead drugs offer the prospect of being followed by back-up compounds. Its chemical structure serves as a starting point for chemical modifications in order to improve potency, selectivity, or pharmacokinetic parameters. Furthermore, newly invented pharmacologically active moieties may have poor druglikeness and may require chemical modification to become drug-like enough to be tested biologically or clinically.[1]
^Hughes, JP; Rees, S; Kalindjian, SB; Philpott, KL (March 2011). "Principles of early drug discovery". British Journal of Pharmacology. 162 (6): 1239–1249. doi:10.1111/j.1476-5381.2010.01127.x. PMC 3058157. PMID 21091654.
A leadcompound (/ˈliːd/, i.e. a "leading" compound, not to be confused with various compounds of the metallic element lead) in drug discovery is a chemical...
a leadcompound series has been established with sufficient target potency and selectivity and favourable drug-like properties, one or two compounds will...
Compounds of lead exist with lead in two main oxidation states: +2 and +4. The former is more common. Inorganic lead(IV) compounds are typically strong...
organolead compounds. Like the lighter members of the group, lead tends to bond with itself; it can form chains and polyhedral structures. Since lead is easily...
found in nature mainly as the sulfide mineral stibnite (Sb2S3). Antimony compounds have been known since ancient times and were powdered for use as medicine...
Lead could be added directly to a ceramic body in the form of a leadcompound in suspension, either from galena (PbS), red lead (Pb3O4), white lead (2PbCO3·Pb(OH)2)...
identify promising leadcompounds. These leadcompounds undergo more extensive optimization in a subsequent step of drug discovery called lead optimization...
Tetraethyllead (commonly styled tetraethyl lead), abbreviated TEL, is an organolead compound with the formula Pb(C2H5)4. It was widely used as a fuel...
use of organic leadcompounds as gasoline additives, but such compounds are still used in industrial settings. Organic leadcompounds, which cross the...
Lead(II) carbonate is the chemical compound with the chemical formula PbCO3. It is a white solid with several practical uses, despite its toxicity. It...
Lead(IV) oxide, commonly known as lead dioxide, is an inorganic compound with the chemical formula PbO2. It is an oxide where lead is in an oxidation state...
bioavailable. It is unlikely to produce useful leads for drug development as a leadcompound. Curcumin was named in 1815 when Henri Auguste Vogel and Pierre Joseph...
initial leadcompound are created and tested as part of a structure–activity relationship study or a database is screened for structural analogs of a lead compound...
Lead zirconate titanate, also called lead zirconium titanate and commonly abbreviated as PZT, is an inorganic compound with the chemical formula Pb[ZrxTi1−x]O3...
Lead oxides are a group of inorganic compounds with formulas including lead (Pb) and oxygen (O). Common lead oxides include: Lead(II) oxide, PbO, litharge...
process of bringing a new pharmaceutical drug to the market once a leadcompound has been identified through the process of drug discovery. It includes...
bioavailability, or modify the activity of the leadcompound, and may alter the metabolism of the lead. Classical bioisosterism was originally formulated...
organolead compounds, which are organometallic compounds containing a chemical bond between carbon and lead. The first organolead compound was hexaethyldilead...
However, it tended to cause lead poisoning, and its use has been banned in most countries. White leadcompounds known as lead soap were also used as additive...
lined with zinc, a reference to Superman's inability to see through lead. Compound V can also bring life back to a dead brain, but limits the cognitive...
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