Pikachurin, also known as AGRINL (AGRINL) and EGF-like, fibronectin type-III and laminin G-like domain-containing protein (EGFLAM), is a protein that in humans is encoded by the EGFLAM gene.[5][6][7]
Pikachurin is a dystroglycan-interacting protein which has an essential role in the precise interactions between the photoreceptor ribbon synapse and the bipolar dendrites.[6] The binding with dystroglycan (DG) depends on several factors (glycosylation of DG, presence of divalent cations, presence of other proteins).
A non-correct binding between pikachurin and DG is associated with muscular dystrophies that often involve eye abnormalities.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000164318 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000042961 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: EGF-like".
^ abSato S, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata K, Funabiki K, Koyasu T, Kajimura N, Miyoshi T, Sawai H, Kobayashi K, Tani A, Toda T, Usukura J, Tano Y, Fujikado T, Furukawa T (August 2008). "Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation". Nature Neuroscience. 11 (8): 923–31. doi:10.1038/nn.2160. PMID 18641643. S2CID 5921645.
^Gu XH, Lu Y, Ma D, Liu XS, Guo SW (October 2009). "[Model of aberrant DNA methylation patterns and its applications in epithelial ovarian cancer.]". Zhonghua Fu Chan Ke Za Zhi (in Chinese). 44 (10): 754–9. PMID 20078962.
^Kanagawa M, Omori Y, Sato S, Kobayashi K, Miyagoe-Suzuki Y, Takeda S, Endo T, Furukawa T, Toda T (October 2010). "Post-translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localization". The Journal of Biological Chemistry. 285 (41): 31208–16. doi:10.1074/jbc.M110.116343. PMC 2951195. PMID 20682766.
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