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Lactase persistence is the continued activity of the lactase enzyme in adulthood, allowing the digestion of lactose in milk. In most mammals, the activity of the enzyme is dramatically reduced after weaning.[1] In some human populations though, lactase persistence has recently evolved[2] as an adaptation to the consumption of nonhuman milk and dairy products beyond infancy. Lactase persistence is very high among northern Europeans, especially Irish people. Worldwide, most people are lactase non-persistent,[1] and are affected by varying degrees of lactose intolerance as adults. However, lactase persistence and lactose intolerance can overlap.
^ abSwallow, Dallas M. (December 2003). "Genetics of Lactase Persistence and Lactose Intolerance". Annual Review of Genetics. 37 (1): 197–219. doi:10.1146/annurev.genet.37.110801.143820. PMID 14616060.
^Bersaglieri, Todd; Sabeti, Pardis C.; Patterson, Nick; Vanderploeg, Trisha; Schaffner, Steve F.; Drake, Jared A.; Rhodes, Matthew; Reich, David E.; Hirschhorn, Joel N. (June 2004). "Genetic Signatures of Strong Recent Positive Selection at the Lactase Gene". The American Journal of Human Genetics. 74 (6): 1111–1120. doi:10.1086/421051. PMC 1182075. PMID 15114531.
and 27 Related for: Lactase persistence information
Lactasepersistence is the continued activity of the lactase enzyme in adulthood, allowing the digestion of lactose in milk. In most mammals, the activity...
the recent evolution of lactasepersistence in some cultures, which extends lactose tolerance into adulthood. Lactasepersistence evolved in several populations...
lactose in breast milk or formula. Some population segments exhibit lactasepersistence resulting from a mutation that is postulated to have occurred 5,000–10...
samples from Yamnaya sites have an allele that is associated with lactasepersistence, conferring lactose tolerance into adulthood. Steppe-derived populations...
to contagious diseases (such as malaria), light skin, blue eyes, lactasepersistence (or the ability to digest milk after weaning), lower blood pressure...
Africa and the Near East, may have been the source population for lactasepersistence variants, including –13910*T, and may have been subsequently supplanted...
Africa and the Near East, may have been the source population for lactasepersistence variants, including –13910*T, and may have been subsequently supplanted...
three new single-nucleotide polymorphisms (SNPs) associated with lactasepersistence (G/C-14010, T/G-13915 and C/G-13907) among ethnic groups in East...
Polymorphism 13.9 kb Upstream of the Lactase Gene (LCT) (C−13.9kbT) Does Not Predict or Cause the Lactase-Persistence Phenotype in Africans". The American...
tested. It has been hypothesized that an allele associated with lactasepersistence (conferring lactose tolerance into adulthood) was brought to Europe...
condition known as lactasepersistence. A study conducted by Sarah Tishkoff and her team shows that the mutation for lactasepersistence has been under positive...
Ségurel, Laure; Bon, Céline (31 August 2017). "On the Evolution of LactasePersistence in Humans". Annual Review of Genomics and Human Genetics. 18 (1):...
East Asian types of ADH1B associated with rice domestication, or lactasepersistence, are due to recent selection pressures. An even more recent adaptation...
hair, and dark or dark-to-black skin, with no genetic adaption for lactasepersistence into adulthood. The near-complete skeleton, an adult male who probably...
Africa and the Near East, may have been the source population for lactasepersistence variants, including –13910*T, and may have been subsequently supplanted...
Culture can profoundly influence gene frequencies in a population. Lactasepersistence One of the best known examples is the prevalence of the genotype...
historically been rare in these regions, due in part to low rates of lactasepersistence. Paneer (pronounced [pəniːr]) is a fresh cheese common in North India...
0132088. PMC 4503422. PMID 26176541. Cramer DW (November 1989). "Lactasepersistence and milk consumption as determinants of ovarian cancer risk". American...
trans-Saharan movement. European autosomal ancestry, mtDNA haplogroups, and lactasepersistence alleles have also been identified in African populations that carry...
moderate amounts of fructose and lactose, particularly if they have lactasepersistence. A low-FODMAP diet consists of the global restriction of all fermentable...
bacteria but not for those infected. Lactasepersistence. A mutation allowed humans to express the enzyme lactase after they are naturally weaned from...
European hunter-gatherers and surprisingly there was no evidence of lactasepersistence at that period. The most recent samples, from the Iron Age, showed...
(2009). "On the edge of Bantu expansions: MtDNA, Y chromosome and lactasepersistence genetic variation in southwestern Angola". BMC Evolutionary Biology...
on lactasepersistence polymorphism of 23 elite and commoner samples from the 10-11th century found that their low prevalence of lactasepersistence "corresponds...
Examples of selective sweeps in humans are in variants affecting lactasepersistence, and adaptation to high altitude. International HapMap Project Hill-Robertson...
known as HFE hereditary haemochromatosis, Y-DNA Haplogroup R-M269, lactasepersistence and blue eyes. Another trait very common in Gaelic populations is...
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