Kalirin, also known as Huntingtin-associated protein-interacting protein (HAPIP), protein duo (DUO), or serine/threonine-protein kinase with Dbl- and pleckstrin homology domain, is a protein that in humans is encoded by the KALRN gene.[5][6] Kalirin was first identified in 1997 as a protein interacting with huntingtin-associated protein 1.[5] Is also known to play an important role in nerve growth and axonal development.[7]
Kalirin is a member of the Dbl family of proteins and is a Rho guanine nucleotide exchange factor.
It is named after the multiple-handed Hindu goddess Kali for its ability to interact with numerous other proteins. Kalirin's other name, DUO, comes from the fact that it is 98% identical to rat DUO protein and 80.6% identical to a human protein named TRIO. Unlike TRIO, which is expressed in numerous tissues, Kalirin isoforms are mainly found in the brain.
^ abcGRCh38: Ensembl release 89: ENSG00000160145 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000061751 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abCite error: The named reference pmid9285789 was invoked but never defined (see the help page).
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Kalirin, also known as Huntingtin-associated protein-interacting protein (HAPIP), protein duo (DUO), or serine/threonine-protein kinase with Dbl- and...
process of regulating spine form and function through its interactions with kalirin-7 (kal-7). Kal-7 is a regulator of spine morphology and synaptic plasticity...
catalyzes the activation of Ran to allow nuclear export of proteins. Ras-GRF1 Kalirin PLEKHG2 Ephexin5 is a RhoA GEF involved in neuronal synapse development...
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