solution structure of the n-terminal zn binding domain of hiv-1 integrase (e form), nmr, 38 structures
Identifiers
Symbol
Integrase_Zn
Pfam
PF02022
InterPro
IPR003308
SCOP2
1wjb / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Integrase core domain
Crystal structure of the RSV two-domain integrase.
Identifiers
Symbol
rve
Pfam
PF00665
Pfam clan
CL0219
InterPro
IPR001584
SCOP2
2itg / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Integrase DNA binding domain
Crystal structure of the RSV two-domain integrase.
Identifiers
Symbol
IN_DBD_C
Pfam
PF00552
InterPro
IPR001037
SCOP2
1ihw / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Retroviral integrase (IN) is an enzyme produced by a retrovirus (such as HIV) that integrates (forms covalent links between) its genetic information into that of the host cell it infects.[1] Retroviral INs are not to be confused with phage integrases (recombinases) used in biotechnology, such as λ phage integrase, as discussed in site-specific recombination.
The macromolecular complex of an IN macromolecule bound to the ends of the viral DNA ends has been referred to as the intasome; IN is a key component in this and the retroviral pre-integration complex.[2]
^Beck BJ, Freudenreich O, Worth JL (2010). "Patients with Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome". Massachusetts General Hospital Handbook of General Hospital Psychiatry. Elsevier. pp. 353–370. doi:10.1016/b978-1-4377-1927-7.00026-1. ISBN 9781437719277.
^Masuda T (2011). "Non-Enzymatic Functions of Retroviral Integrase: The Next Target for Novel Anti-HIV Drug Development". Frontiers in Microbiology. 2: 210. doi:10.3389/fmicb.2011.00210. PMC 3192317. PMID 22016749.
Retroviral integrase (IN) is an enzyme produced by a retrovirus (such as HIV) that integrates (forms covalent links between) its genetic information into...
Integrase inhibitors (INIs) are a class of antiretroviral drug designed to block the action of integrase, a viral enzyme that inserts the viral genome...
version of its genome into the host cell DNA is called its "integrase". HIV-1 integrase catalyzes the “cut-and-paste” action of clipping the host DNA...
(backwards). The new DNA is then incorporated into the host cell genome by an integrase enzyme, at which point the retroviral DNA is referred to as a provirus...
endowed with an RT (reverse-transcriptase) and an RNAse H domains, and an integrase (IN). Typically, LTR-retrotransposon mRNAs are produced by the host RNA...
specific recombination events. The enzyme (38 kDa) is a member of the integrase family of site specific recombinase and it is known to catalyse the site...
non-catalytic site integrase inhibitor (NCINI). It inhibits HIV replication via binding to a conserved allosteric pocket of the HIV integrase enzyme. This makes...
(insufflation), a method of administrating some medications and vaccines Integrase, a retroviral enzyme In (album), by the Outsiders, 1967 In (Korean name)...
viral RNA. Another target is integrase, which integrate the synthesized DNA into the host cell genome. Examples of integrase inhibitors include raltegravir...
early stages of genome replication, and include reverse transcriptase and integrase. Reverse transcriptase is the virally encoded RNA-dependent DNA polymerase...
breastfeeding is safe. Dolutegravir is an HIV integrase strand transfer inhibitor which blocks the functioning of HIV integrase which is needed for viral replication...
The WHO Model List of Essential Medicines (aka Essential Medicines List or EML), published by the World Health Organization (WHO), contains the medications...
make development difficult. Integrase is a viral enzyme that integrates retroviral DNA into the host cell genome. Integrase inhibitors are a new class...
nucleus and integrated into the cellular DNA by a virally encoded enzyme, integrase, and host co-factors. Once integrated, the virus may become latent, allowing...
use in children, and agreed to negotiate a license for dolutegravir, an integrase inhibitor then in clinical development. In 2014, this license was extended...
Viruses can also contain enzymes for infecting cells, such as the HIV integrase and reverse transcriptase, or for viral release from cells, like the influenza...
breastfeeding is safe. Raltegravir is an HIV integrase strand transfer inhibitor which blocks the functioning of HIV integrase which is needed for viral replication...
Theoretical physicist Daria Hazuda, 1989, biochemist; discovered the first HIV Integrase Strand Transfer Inhibitors Carl Heastie, 1990, Speaker of the New York...
Bictegravir (INN; BIC, formerly known as GS-9883) is a second-generation integrase inhibitor (INSTI) class that was structurally derived from an earlier...
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