Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Inosine triphosphate (ITP) is an intermediate in the purine metabolism pathway, seen in the synthesis of ATP and GTP. It comprises an inosine nucleotide containing three phosphate groups esterified to the sugar moiety.
ITP results from deamination of ATP. Incorporation of ITP into the DNA from the nucleotide pool can lead to DNA damage, mutagenesis and other harmful effects.[1] ITP is processed by the enzyme inosine triphosphate pyrophosphatase (ITPA), which turns it into inosine monophosphate (IMP), to avoid incorporation into DNA.[1]
^ abJi D, Stepchenkova EI, Cui J, Menezes MR, Pavlov YI, Kool ET (November 2017). "Measuring deaminated nucleotide surveillance enzyme ITPA activity with an ATP-releasing nucleotide chimera". Nucleic Acids Research. 45 (20): 11515–11524. doi:10.1093/nar/gkx774. PMC 5714213. PMID 29036687.
and 27 Related for: Inosine triphosphate information
Inosinetriphosphate (ITP) is an intermediate in the purine metabolism pathway, seen in the synthesis of ATP and GTP. It comprises an inosine nucleotide...
monophosphate by AMP deaminase. It can be hydrolysed to inosine. The enzyme deoxyribonucleoside triphosphate pyrophosphohydrolase, encoded by YJR069C in Saccharomyces...
Inosinetriphosphate pyrophosphatase is an enzyme that in humans is encoded by the ITPA gene, by the rdgB gene in bacteria E.coli and the HAM1 gene in...
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triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase. Deoxyadenosine triphosphate is...
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A nucleoside triphosphate is a nucleoside containing a nitrogenous base bound to a 5-carbon sugar (either ribose or deoxyribose), with three phosphate...
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thiopurine S-methyltransferase (TPMT), nudix hydrolase 15 (NUDT15), and inosinetriphosphate pyrophosphatase (ITPA). People with specific allele variants will...
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nucleotide inosine monophosphate (IMP), which is the first compound in the pathway to have a completely formed purine ring system. Inosine monophosphate...
cellular respiration, in the form of both the energy-rich adenosine triphosphate (ATP) and the cofactors nicotinamide adenine dinucleotide (NAD), flavin...
proteins or protein domains, such as P1-PISPO, Alkylation B (AlkB), and inosinetriphosphate pyrophosphatase (known as ITPase or HAM1). Such anomalies are often...
nucleotides classified as purines. In purine synthesis, PRPP is turned into inosine monophosphate, or IMP. Production of IMP from PRPP requires glutamine,...
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species, for instance some ipomoviruses lack HC and have a P1 tandem. Inosinetriphosphate pyrophosphatase (known as ITPase or HAM1) is an atypical protein...
many cellular metabolic processes, being interconverted to adenosine triphosphate (ATP) and adenosine diphosphate (ADP), as well as allosterically activating...
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where it is present in the anticodon of tRNA in the form of its nucleoside inosine. It has a tautomer known as 6-hydroxypurine. Hypoxanthine is a necessary...
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