Biological response modifiers (BRMs) are substances that modify immune responses. They can be endogenous (produced naturally within the body) or exogenous (as pharmaceutical drugs), and they can either enhance an immune response or suppress it. Some of these substances arouse the body's response to an infection, and others can keep the response from becoming excessive. Thus they serve as immunomodulators in immunotherapy (therapy that makes use of immune responses), which can be helpful in treating cancer (where targeted therapy often relies on the immune system being used to attack cancer cells) and in treating autoimmune diseases (in which the immune system attacks the self), such as some kinds of arthritis and dermatitis. Most BRMs are biopharmaceuticals (biologics), including monoclonal antibodies, interleukin 2, interferons, and various types of colony-stimulating factors (e.g., CSF, GM-CSF, G-CSF).[1] "Immunotherapy makes use of BRMs to enhance the activity of the immune system to increase the body's natural defense mechanisms against cancer",[2] whereas BRMs for rheumatoid arthritis aim to reduce inflammation.
Some conditions which biologics are used to treat are rheumatic disorders[3] such as psoriatic arthritis,[4] ankylosing spondylitis and non-radiographic axial spondyloarthritis,[5] and inflammatory bowel disease.[6]
^"Definition of Biological response modifiers". medterms.com. MedicineNet.com. Archived from the original on 2012-08-04.
^"Biological Response Modifiers (BRM)".
^Cite error: The named reference Singh 2009 was invoked but never defined (see the help page).
^Cite error: The named reference Consumer Reports Biologics was invoked but never defined (see the help page).
^Ward, MM; Deodhar, A; Gensler, LS; Dubreuil, M; Yu, D; Khan, MA; Haroon, N; Borenstein, D; Wang, R; Biehl, A; Fang, MA; Louie, G; Majithia, V; Ng, B; Bigham, R; Pianin, M; Shah, AA; Sullivan, N; Turgunbaev, M; Oristaglio, J; Turner, A; Maksymowych, WP; Caplan, L (October 2019). "2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis". Arthritis Care & Research. 71 (10): 1285–1299. doi:10.1002/acr.24025. PMC 6764857. PMID 31436026.
^D'Haens, G. (1 May 2007). "Risks and benefits of biologic therapy for inflammatory bowel diseases". Gut. 56 (5): 725–732. doi:10.1136/gut.2006.103564. PMC 1942157. PMID 17440187.
and 20 Related for: Biological response modifier information
Biologicalresponsemodifiers (BRMs) are substances that modify immune responses. They can be endogenous (produced naturally within the body) or exogenous...
the mutualitic and symbiotic approach being much more likely. Biologicalresponsemodifier Sepsivac Checkpoint inhibitor Interleukin-2 immunotherapy Immunostimulant...
include the following: disease-modifying antirheumatic drugs, biologicresponsemodifiers, analgesics, non-steroidal anti-inflammatory drugs, and corticosteroids...
countries for use as an anti-tumor drug. It appears to work as a biologicalresponsemodifier (BRM), enhancing the body's own use of macrophages and T-lymphocytes...
T.; et al. (1993). "Eisenin (L-pyroGlu-L-Gln-L-Ala), a new biologicalresponsemodifier". Journal of Immunotherapy. 13 (1): 36–42. doi:10.1097/00002371-199301000-00005...
evolution of drug delivery concept from inert nanocarriers to biologicalresponsemodifiers". Journal of Controlled Release. 130 (2): 98–106. doi:10.1016/j...
innovative treatment strategies for allergic diseases which includes biologicalresponsemodifier in form of targeted immunotherapy with primary emphasis on sublingual...
In relation to diseases, thymosins have been categorized as biologicalresponsemodifiers. Thymosins are important for proper T-cell development and differentiation...
TNF inhibitor-type biological disease-modifying anti-rheumatic drug (DMARD). Biologics (also called biologicalresponsemodifiers) are a class of therapeutics...
glucose polymers commonly called beta-glucans demonstrating biologicalresponsemodifier properties. These immunomodulating properties render the host...
(2017-07-01). "Additional Improvements in Clinical Response From Adjuvant BiologicResponseModifiers in Adults With Moderate to Severe Systemic Lupus Erythematosus...
immunology. Thus, as immunomodulators, they are one type of biologicalresponsemodifiers. The most successful targeted therapies are chemical entities...
A human disease modifier gene is a modifier gene that alters expression of a human gene at another locus that in turn causes a genetic disease. Whereas...
; BeMiller, James N. (January 1995). "(1→3)-β-d-Glucans as biologicalresponsemodifiers: a review of structure-functional activity relationships". Carbohydrate...
Inflammation (from Latin: inflammatio) is part of the biologicalresponse of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants...
Global Information