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The idiotype is based upon the variable region (labeled VL and VH in the diagram.)
In immunology, an idiotype is a shared characteristic between a group of immunoglobulin or T-cell receptor (TCR) molecules based upon the antigen binding specificity and therefore structure of their variable region. The variable region of antigen receptors of T cells (TCRs) and B cells (immunoglobulins) contain complementarity-determining regions (CDRs) with unique amino acid sequences. They define the surface and properties of the variable region, determining the antigen specificity and therefore the idiotope of the molecule. Immunoglobulins or TCRs with a shared idiotope are the same idiotype. Antibody idiotype is determined by:
Gene rearrangement
Junctional diversity
P-nucleotides (palindromic nucleotides at sites of single-strand breaks)
In immunology, an idiotype is a shared characteristic between a group of immunoglobulin or T-cell receptor (TCR) molecules based upon the antigen binding...
each of which matches a different lock (antibody). Different antibody idiotypes, each have distinctly formed complementarity-determining regions. Allergen...
immunoglobulin (idiotype or Id). Id-secreting clones are identified by a bioinformatics approach which confirms a match of each vaccine's unique idiotype sequence...
inactivated in the normal individual and cannot amplify the immune response. Idiotype network theory, proposed by Jerne, wherein a network of antibodies capable...
the active sites of antibodies are attracted to both specific antigens (idiotypes) and to other antibodies that bind to the same site. The antibodies are...
multiple idiotopes; and the set of these individual idiotopes is termed the idiotype of the antibody. Idiotopes contrast with allotopes, which are non-varying...
Retrieved 27 November 2020. Yewdell J (4 October 2003). "He put the Id in Idiotype". EMBO Reports (Book review). 4 (10): 931. doi:10.1038/sj.embor.embor951...
are also called idiotypes. According to immune network theory, the adaptive immune system is regulated by interactions between idiotypes. The Fc region...
Goldman, M; Rose, LM; Hochmann, A; Lambert, PH (1982). "Deposition of idiotype-anti-idiotype immune complexes in renal glomeruli after polyclonal B cell activation"...
the variable portion of an antibody) and 'anti-idiotypes' (antigen receptors that react with the idiotype as if it were a foreign antigen). This theory...
lead scientific advisor for a new biotech company specializing in 'anti-idiotypes,' a novel vaccine technology." Salk called the proposal "liberating."...
(idiotype) and activate CD4+ T cells. Proc Natl Acad Sci U S A. Mar 14;97(6):2697-702. PMID 10706628 Fredriksen AB, Bogen B. (2007) Chemokine-idiotype...
the role of antibodies in brain disease. Diamond identified the first idiotype marker on anti-DNA antibodies in patients with lupus, and discovered that...
Plasmodium falciparum malaria-infected erythrocytes identified by anti-idiotype antibodies". Proceedings of the National Academy of Sciences of the United...
Abagovomab is a mouse anti-idiotype monoclonal antibody whose variable epitope mirrors a tumour antigen (CA-125) highly expressed in the epithelial ovarian...
A.M, Hernández, A.M., Macías, A., et al. (2012). Racotumomab: an anti-idiotype vaccine related to N-glycolyl-containing gangliosides – preclinical and...
commonly have variable heavy-chain regions encoded by VH, with a distinct idiotype identified by the 9G4 rat murine monoclonal antibody. AIHA can be classified...
Hybridoma technology Hyperimmune globulin Hypersensitive response Idiotopes Idiotype IL 10 family IL 17 family IL-12 and IL-12 Receptor β1 Mutations IL-2 receptor...
"Autoimmunization Against Hormones: A New Strategy in Animal Production". Anti-Idiotypes, Receptors, and Molecular Mimicry. pp. 245–254. doi:10.1007/978-1-4612-3734-1_15...
Hernández AM, Pérez A, Rodríguez E, Bitton R, et al. (March 2002). "An anti-idiotype vaccine elicits a specific response to N-glycolyl sialic acid residues...
L; Alonso, DF; Chantada, GL (July 2015). "A phase I study of the anti-idiotype vaccine racotumomab in neuroblastoma and other pediatric refractory malignancies"...
Iliev AA, Livneh A, Diamond B (December 1992). "The anti-DNA-associated idiotype 8.12 is encoded by the V lambda II gene family and maps to the vicinity...
study-grade antibodies development Molecular modeling Antibody sequencing Anti-idiotype antibody production Anti-protein antibodies for pharmacokinetics studies...
(October 2000). "Tumor-specific recognition of human myeloma cells by idiotype-induced CD8(+) T cells". Blood. 96 (8): 2828–33. doi:10.1182/blood.V96...
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