In genetics a hypersensitive site is a short region of chromatin and is detected by its super sensitivity to cleavage by DNase I and other various nucleases (DNase II and micrococcal nucleases). In a hypersensitive site, the nucleosomal structure is less compacted, increasing the availability of the DNA to binding by proteins, such as transcription factors and DNase I. These sites account for many inherited tendencies.[2]
^Wang, YM; Zhou, P; Wang, LY; Li, ZH; Zhang, YN; Zhang, YX (2012). "Correlation between DNase I hypersensitive site distribution and gene expression in HeLa S3 cells". PLOS ONE. 7 (8): e42414. Bibcode:2012PLoSO...742414W. doi:10.1371/journal.pone.0042414. PMC 3416863. PMID 22900019.
^Pennisi, Elizabeth (7 September 2012). "ENCODE Project Writes Eulogy for Junk DNA". Science. 337 (6099): 1159–1161. Bibcode:2012Sci...337.1159P. doi:10.1126/science.337.6099.1159. PMID 22955811.
and 24 Related for: Hypersensitive site information
In genetics a hypersensitivesite is a short region of chromatin and is detected by its super sensitivity to cleavage by DNase I and other various nucleases...
In genetics, DNase I hypersensitivesites (DHSs) are regions of chromatin that are sensitive to cleavage by the DNase I enzyme. In these specific regions...
Hypersensitivity (also called hypersensitivity reaction or intolerance) is an abnormal physiological condition in which there is an undesirable and adverse...
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the carotid bifurcation. It is a condition known as 'carotid sinus hypersensitivity' (CSH), 'carotid sinus syndrome' or 'carotid sinus syncope', in which...
not strongly supported or precluded. Transcription factors bind to hypersensitivesite cores and cause the LCR to form a loop that can interact with the...
digestion, which cleaves DNA in a low sequence specificity manner. Such hypersensitivesites were thought to be transcriptionally active regions, as evidenced...
"methylome". DNase chip is an application of tiling arrays to identify hypersensitivesites, segments of open chromatin that are more readily cleaved by DNaseI...
Schiff base with K119 in the active site. Between the catalytic and regulatory domains exists a hypersensitivesite that causes proteolytic cleavage and...
resolution down to basepair level. Chromatin Accessibility – DNase I hypersensitivesites Sequencing (DNase-Seq) uses the DNase I enzyme to find open or accessible...
both the presence and activity of transcription start sites. Distal DNaseI hypersensitivesites have characteristic histone modification patterns that...
functional dyspepsia and irritable bowel syndrome. Visceral hypersensitivity is hypersensitive visceral pain perception, which is commonly experienced by...
Krangel MS (1999). "Enhancer-blocking activity within the DNase I hypersensitivesite 2 to 6 region between the TCR alpha and Dad1 genes". J. Immunol....
ChIP-Seq, or gaps where the DNA is not packaged by histones (DNase hypersensitivesites), both of which tell where there are active regulatory sequences...
laureate Walter Gilbert, where he provided the first evidence for DNase hypersensitivesites at cellular gene promoters. In 1982, Wu joined the National Cancer...
Hawrylycz M, et al. (March 2004). "Genome-wide identification of DNaseI hypersensitivesites using active chromatin sequence libraries". Proc. Natl. Acad. Sci...
eosinophilia and systemic symptoms (DRESS), also termed drug-induced hypersensitivity syndrome (DIHS), is a rare reaction to certain medications. It involves...
insertion preference for near genes, transcription start sites, CpG islands, and DNaseI hypersensitivesites in comparison to piggyBac. These elements were first...
but have not been thoroughly characterized. In genomics, DNase I hypersensitivesites are thought to be characterized by open, accessible chromatin; therefore...
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