Hypergonadotropic hypogonadism (HH), also known as primary or peripheral/gonadal hypogonadism or primary gonadal failure, is a condition which is characterized by hypogonadism which is due to an impaired response of the gonads to the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and in turn a lack of sex steroid production.[1] As compensation and the lack of negative feedback, gonadotropin levels are elevated. Individuals with HH have an intact and functioning hypothalamus and pituitary glands (of the hypothalamic-pituitary-gonadal (HPA) axis) so they are still able to produce FSH and LH.[1] HH may present as either congenital or acquired, but the majority of cases are of the former nature.[2][3] HH can be treated with hormone replacement therapy.[4]
^ abFerguson AM, Cervinski MA (2021). "Chapter 5 – Endocrine disorders of the reproductive system". In Winter WE, Holmquist B, Sokoll LJ, Bertholf RL (eds.). Handbook of Diagnostic Endocrinology (Third ed.). Academic Press. pp. 157–180. doi:10.1016/B978-0-12-818277-2.00005-4. ISBN 978-0-12-818277-2. S2CID 225119774. Retrieved 2022-07-28.
^Mulhall JP (2011). Cancer and Sexual Health. Springer. pp. 207–208. ISBN 978-1-60761-915-4. Retrieved 10 June 2012.
^Piñón R (2002). Biology of Human Reproduction. University Science Books. p. 363. ISBN 978-1-891389-12-2. Retrieved 10 June 2012.
^"Low Sex Drive (Hypogonadism): Symptoms, Treatment". Cleveland Clinic. Retrieved 2022-07-28.
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