CTAG1B information

CTAG1B
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1S9W, 2BNQ, 2BNR, 2F53, 2F54, 2P5E, 2P5W, 2PYE, 3GJF, 3HAE, 3KLA
Identifiers
Aliases	CTAG1B, CT6.1, CTAG, CTAG1, ESO1, LAGE-2, LAGE2B, NY-ESO-1, cancer/testis antigen 1B
External IDs	OMIM: 300156 HomoloGene: 133254 GeneCards: CTAG1B
Gene location (Human)
Chr.	X chromosome (human)
End	154,619,282 bp
RNA expression pattern
	Top expressed in
	testicle; ; stromal cell of endometrium; ; skeletal muscle tissue; ; cerebellum; ; cerebellar cortex; ; cerebellar hemisphere; ; Brodmann area 9; ; prefrontal cortex; ; blood; ; gastrocnemius muscle;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Orthologs
	1485
	n/a
	ENSG00000184033
	n/a
	P78358
	n/a
	NM_001327
	n/a
	NP_640343; NP_001318
	n/a
	Wikidata
View/Edit Human

Cancer/testis antigen 1 also known as LAGE2 or LAGE2B is a protein that in humans is encoded by the CTAG1B gene.^[3]^[4]^[5] It is most often referenced by its alias NY-ESO-1.

Cancer/Testis Antigen 1B is a protein belonging to the family of Cancer Testis Antigens (CTA) that are expressed in a variety of malignant tumours at the mRNA and protein levels, but also restricted to testicular germ cells in normal adult tissues. A clone of CTAG gene was originally identified by immunological methods in oesophageal carcinoma using patient serum.^[6] The aberrant re-expression of CTAs is induced by molecular mechanisms including DNA demethylation, histone post-translational modification, and microRNA-mediated regulation. The effect of DNA demethylation is evident by the capability of demethylating agents, such as 5-aza-2-deoxycytidine, to induce CTAs re-expression in tumour cells but not in normal epithelial cells.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184033 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen YT, Boyer AD, Viars CS, Tsang S, Old LJ, Arden KC (Jun 1998). "Genomic cloning and localization of CTAG, a gene encoding an autoimmunogenic cancer-testis antigen NY-ESO-1, to human chromosome Xq28". Cytogenetics and Cell Genetics. 79 (3–4): 237–40. doi:10.1159/000134734. PMID 9605863.
^ Aradhya S, Bardaro T, Galgóczy P, Yamagata T, Esposito T, Patlan H, Ciccodicola A, Munnich A, Kenwrick S, Platzer M, D'Urso M, Nelson DL (October 2001). "Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes". Human Molecular Genetics. 10 (22): 2557–67. doi:10.1093/hmg/10.22.2557. PMID 11709543.
^ "Entrez Gene: CTAG1B cancer/testis antigen 1B".
^ Chen YT, Scanlan MJ, Sahin U, Türeci O, Gure AO, Tsang S, Williamson B, Stockert E, Pfreundschuh M, Old LJ (March 1997). "A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening". Proceedings of the National Academy of Sciences of the United States of America. 94 (5): 1914–8. Bibcode:1997PNAS...94.1914C. doi:10.1073/pnas.94.5.1914. PMC 20017. PMID 9050879.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184033 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9605863-3] Chen YT, Boyer AD, Viars CS, Tsang S, Old LJ, Arden KC (Jun 1998). "Genomic cloning and localization of CTAG, a gene encoding an autoimmunogenic cancer-testis antigen NY-ESO-1, to human chromosome Xq28". Cytogenetics and Cell Genetics. 79 (3–4): 237–40. doi:10.1159/000134734. PMID 9605863.

[pmid11709543-4] Aradhya S, Bardaro T, Galgóczy P, Yamagata T, Esposito T, Patlan H, Ciccodicola A, Munnich A, Kenwrick S, Platzer M, D'Urso M, Nelson DL (October 2001). "Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes". Human Molecular Genetics. 10 (22): 2557–67. doi:10.1093/hmg/10.22.2557. PMID 11709543.

[entrez-5] "Entrez Gene: CTAG1B cancer/testis antigen 1B".

[:0-6] Chen YT, Scanlan MJ, Sahin U, Türeci O, Gure AO, Tsang S, Williamson B, Stockert E, Pfreundschuh M, Old LJ (March 1997). "A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening". Proceedings of the National Academy of Sciences of the United States of America. 94 (5): 1914–8. Bibcode:1997PNAS...94.1914C. doi:10.1073/pnas.94.5.1914. PMC 20017. PMID 9050879.

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