The hot plate test is a test of the pain response in animals, similar to the tail flick test. Both hot plate and tail-flick methods are used generally for centrally acting analgesic,[1] while peripherally acting drugs are ineffective in these tests but sensitive to acetic acid-induced writhing test.[2]
The hot plate test is used in basic pain research and in testing the effectiveness of analgesics by observing the reaction to pain caused by heat. It was proposed by Eddy and Leimbach in 1953.[3] They used a behavioral model of nociception where behaviors such as jumping and hind paw-licking are elicited following a noxious thermal stimulus. Licking is a rapid response to painful thermal stimuli that is a direct indicator of nociceptive threshold. Jumping represents a more elaborated response, with a latency, and encompasses an emotional component of escaping.[4]
^Carlsson, Karl-Heinz; Jurna, Ilmar (1987). "Depression by flupirtine, a novel analgesic agent, of motor and sensory responses of the nociceptive system in the rat spinal cord". European Journal of Pharmacology. 143 (1): 89–99. doi:10.1016/0014-2999(87)90738-2. ISSN 0014-2999. PMID 3691652.
^Matera, Carlo; Flammini, Lisa; Quadri, Marta; Vivo, Valentina; Ballabeni, Vigilio; Holzgrabe, Ulrike; Mohr, Klaus; De Amici, Marco; Barocelli, Elisabetta; Bertoni, Simona; Dallanoce, Clelia (2014). "Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: Synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity". European Journal of Medicinal Chemistry. 75: 222–232. doi:10.1016/j.ejmech.2014.01.032. ISSN 0223-5234. PMID 24534538.
^Eddy, NB; Leimbach, D (1953). "Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines". J Pharmacol Exp Ther. 107 (3): 385–393. PMID 13035677.
^ESPEJO, E; Mir, D (30 September 1993). "Structure of the rat's behaviour in the hot plate test". Behavioural Brain Research. 56 (2): 171–176. doi:10.1016/0166-4328(93)90035-O. PMID 8240711. S2CID 4022669.
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