A homologous booster shot involves the administration of the same vaccine as previously administered, while a heterologous booster shot involves the administration of a different vaccine.[citation needed]
"Heterologous prime-boost immunization is administration of two different vectors or delivery systems expressing the same or overlapping antigenic inserts."[1]
"An effective vaccine usually requires more than one time immunization in the form of prime-boost. Traditionally the same vaccines are given multiple times as homologous boosts. New findings suggested that prime-boost can be done with different types of vaccines containing the same antigens. In many cases such heterologous prime-boost can be more immunogenic than homologous prime-boost."[2]
^"WHO Technical Consultation: Heterologous Prime-Boost Immunization in Ebola vaccine development and testing, licensure and use; 21 November 2014" (PDF). World Health Organization. Geneva. 2015-02-09. Archived (PDF) from the original on 10 December 2021. Retrieved 10 December 2021.
^Lu, S (June 2009). "Heterologous prime-boost vaccination". Current Opinion in Immunology. 21 (3): 346–51. doi:10.1016/j.coi.2009.05.016. PMC 3743086. PMID 19500964.
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