Hereditary lobular breast cancer is a rare inherited cancer predisposition associated with pathogenic CDH1 (gene) germline mutations, and without apparent correlation with the hereditary diffuse gastric cancer syndrome. Research studies identified novel CDH1 germline variants in women with diagnosed lobular breast cancer (in invasive and/or in situ histotype) and without any family history of gastric carcinoma. Firstly, in 2018 Giovanni Corso et al. defined this syndrome as a new cancer predisposition and the Authors suggested additional clinical criteria to testing CDH1 in lobular breast cancer patients.[1]
In 2020, the International Gastric Cancer Linkage Consortium recognized officially that the hereditary lobular breast cancer is a possible independent syndrome.[2] To date, there are reported about 40 families clustering for lobular breast cancer and associated with CDH1 germline mutations but without association with diffuse gastric cancer. Other recent studies demonstrated a possible correlation between hereditary lobular breast cancer and gastric cancer risk.[3][4]
^Corso, Giovanni (2018). "Hereditary lobular breast cancer with an emphasis on E-cadherin genetic defect". Journal of Medical Genetics. 55 (7): 431–441. doi:10.1136/jmedgenet-2018-105337. PMID 29929997. S2CID 206998695.
Hereditarylobularbreastcancer is a rare inherited cancer predisposition associated with pathogenic CDH1 (gene) germline mutations, and without apparent...
develop this form of cancer by age 80. Female patients are also estimated to have a 42% lifetime risk of developing lobularbreastcancer. The median age of...
Male breastcancer (MBC) is a cancer in males that originates in their breasts. Males account for less than 1% of new breastcancers with about 20,000...
factors for breastcancer may be divided into preventable and non-preventable. Their study belongs in the field of epidemiology. Breastcancer, like other...
Journal of Cancer Prevention. His main research activities are on hereditary diffuse gastric cancer and hereditarylobularbreastcancer associated with...
developing from lobules are known as lobular carcinomas. There are more than 18 other sub-types of breastcancer. Some, such as ductal carcinoma in situ...
triple-negative breastcancer (15%–25% of breastcancers), HER2+ (15%–30% of breastcancers), ER+/PR+ (about 70% of breastcancers), and Invasive lobular carcinoma...
form of breastcancer, lobularcancer, has a growth pattern that produces shadows on the mammogram that are indistinguishable from normal breast tissue...
three-quarters of breastcancers: Invasive ductal carcinoma: 55% of breastcancers Ductal carcinoma in situ: 13% Invasive lobular carcinoma: 5% The vast...
implications for risk of early-onset breast cancer in young women from hereditarybreastcancer families". Br. J. Cancer. 92 (5): 857–66. doi:10.1038/sj.bjc.6602389...
"The association between cholangiocarcinoma and hereditary nonpolyposis colorectal carcinoma". Cancer. 69 (5): 1112–4. doi:10.1002/cncr.2820690508. PMID 1310886...
treating the underlying cancer. The incidence of the disease varies according to geographic, demographic and, to a lesser extent, hereditary factors. There are...
primary liver cancer in adults and is currently the most common cause of death in people with cirrhosis. HCC is the third leading cause of cancer-related deaths...
Sohrab P. Shah; et al. (October 2009). "Mutational evolution in a lobularbreast tumour profiled at single nucleotide resolution". Nature. 461 (7265):...
into colon cancer occurs when they are left untreated. Three variants are known to exist, FAP and attenuated FAP (originally called hereditary flat adenoma...
rare inherited mutations in E-cadherin. The hereditary form of this cancer, hereditary diffuse gastric cancer, accounts for only 1–3% of gastric adenocarcinomas...
predisposes individuals to renal cell cancer, an association denominated hereditary leiomyomatosis and renal cell cancer. It is also associated with increased...
authorities also refer to hereditary genetic conditions which predispose to developing cancer, such as hereditary nonpolyposis colorectal cancer, as a precancerous...
Fallopian Tube Cancer". accessed 08-14-2008 BRCA mutations link to tubal cancer, accessed 08-14-2008 Piek, J. M. J. (2004). Hereditary serous ovarian...
phenotype. Multiple Endocrine Neoplasia type 1 (MEN1) is a rare hereditary endocrine cancer syndrome characterized primarily by tumors of the parathyroid...
form of cancer is often seen in those who chew tobacco or use snuff orally, so much so that it is sometimes referred to as "Snuff dipper's cancer". Age –...
hereditary conditions, patients with hereditary papillary renal cancer syndrome showed a greater risk of type 1 PRCC, whereas those with hereditary leiomyomatosis...
breakthrough pain – breastcancer in situ – breast density – breast duct endoscopy – Breast Imaging Reporting and Data System – breast implant – breast reconstruction...
structure of this tissue is composed of septal (i.e. linear strands) and lobular compartments, which differ in microscopic appearance. Functionally, the...
structure of this tissue is composed of septal (i.e. linear strands) and lobular compartments, which differ in microscopic appearance. Functionally, the...
acini. Generally, in acute bacterial and viral sialadenitis cases, the lobular architecture of the gland is maintained or may be slightly expanded. Areas...
led to the development of tongue SCC. In mice predisposed to invasive lobularbreast carcinoma (ILBC) because of E-cadherin ablation, the inactivation of...
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