Micrograph of a neuroendocrine tumour of the stomach. H&E stain.
Specialty
General surgery
Gastrinomas are neuroendocrine tumors (NETs), usually located in the duodenum or pancreas, that secrete gastrin and cause a clinical syndrome known as Zollinger–Ellison syndrome (ZES).[1][2][3] A large number of gastrinomas develop in the pancreas or duodenum, with near-equal frequency, and approximately 10% arise as primary neoplasms in lymph nodes of the pancreaticoduodenal region (gastrinoma triangle).[4]
Most gastrinomas are sporadic (75–80%), whereas approximately 20–25% are associated with multiple endocrine neoplasia type 1 (MEN-1).[5] Over 50% of gastrinomas are malignant and can metastasize to regional lymph nodes and liver. One fourth of gastrinomas are related to multiple endocrine neoplasia type 1, Zollinger–Ellison syndrome, peptic ulcer disease.[6]
^Jensen, Robert T.; Niederle, Bruno; Mitry, Emmanuel; Ramage, John K.; Steinmüller, Thomas; Lewington, V.; Scarpa, Aldo; Sundin, Anders; Perren, Aurel; Gross, David; O’Connor, Juan M. (2006). "Gastrinoma (Duodenal and Pancreatic)". Neuroendocrinology. 84 (3): 173–182. doi:10.1159/000098009. ISSN 0028-3835. PMID 17312377. S2CID 5096249.
^Feelders, Richard A.; Hofland, Leo J.; Kwekkeboom, Dik J.; Lamberts, StevenW.; de Herder, Wouter W. (2012). "Neuroendocrine Tumors". Handbook of Neuroendocrinology. Elsevier. pp. 761–778. doi:10.1016/b978-0-12-375097-6.10035-6. ISBN 9780123750976. Gastrinomas overproduce gastrin, resulting in increased gastric acid production, which in turn leads to the Zollinger-Ellison syndrome, characterized by (severe) peptic ulcers, gastroesophageal reflux and diarrhea.
^Cite error: The named reference Cingam Botejue Hoilat Karanchi 2022 p. was invoked but never defined (see the help page).
^Yantiss, RHONDA K.; Antonioli, DONALD A. (2009-01-01), Odze, ROBERT D.; Goldblum, JOHN R. (eds.), "CHAPTER 18 – Polyps of the Small Intestine", Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas (Second Edition), Philadelphia: W.B. Saunders, p. 473, ISBN 978-1-4160-4059-0, retrieved 2020-12-18
^Cite error: The named reference :5 was invoked but never defined (see the help page).
^Cite error: The named reference :2 was invoked but never defined (see the help page).
Gastrinomas are neuroendocrine tumors (NETs), usually located in the duodenum or pancreas, that secrete gastrin and cause a clinical syndrome known as...
inhibitory peptide (GIP), secretin, somatostatin, glucagon, calcitonin Gastrinoma paraneoplastic oversecretion (see Role in disease) In the Zollinger–Ellison...
often classified by the hormone most strongly secreted, for example: gastrinoma: the excessive gastrin causes Zollinger–Ellison syndrome (ZES) with peptic...
MEN type who develop the neoplasia type. *- of patients with MEN1 and gastrinoma FMTC = familial medullary thyroid cancer MEN 2B is sometimes known as...
pancreatic tumours (insulin, glucagon), by Verner-Morrison syndrome, and by gastrinoma. Polypeptide-p Pancreas List of human cell types derived from the germ...
octreotide attaches to tumor cells that have receptors for somatostatin (i.e. gastrinoma, glucagonoma, etc.). A gamma camera detects the radioactive octreotide...
7 and 16.8 minutes. In humans, an over production of this hormone by gastrinomas leads to Zollinger-Ellison Syndrome. Big Gastrin Responses to Foods:...
early detection. The most common functioning PanNETs are insulinomas and gastrinomas, named after the hormones they secrete. The nonfunctioning types do not...
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