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GNAL information


GNAL
Identifiers
AliasesGNAL, DYT25, G protein subunit alpha L, HG1O
External IDsOMIM: 139312; MGI: 95774; HomoloGene: 68222; GeneCards: GNAL; OMA:GNAL - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_010307
NM_177137

RefSeq (protein)

NP_001135811
NP_001248372
NP_001248373
NP_892023
NP_001356316

NP_034437
NP_796111

Location (UCSC)Chr 18: 11.69 – 11.89 MbChr 18: 67.22 – 67.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide-binding protein G(olf) subunit alpha is a protein that in humans is encoded by the GNAL gene.[5][6] Its main product is the heterotrimeric G-protein alpha subunit Golf-α, a member of the Gs alpha subunit family that is a key component of G protein-coupled receptor-regulated adenylyl cyclase signal transduction pathways in the olfactory system and the striatum in the brain. It also mediated D1 receptor signalling in the striatum and is hence involved in motor control.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141404 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024524 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI, et al. (Jun 1993). "Evolution of the mammalian G protein alpha subunit multigene family". Nat Genet. 1 (2): 85–91. doi:10.1038/ng0592-85. PMID 1302014. S2CID 31888533.
  6. ^ "Entrez Gene: GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type".
  7. ^ Zhuang X, Belluscio L, Hen R (15 August 2000). "GOLFα Mediates Dopamine D 1 Receptor Signaling". The Journal of Neuroscience. 20 (16): RC91. doi:10.1523/JNEUROSCI.20-16-j0001.2000. PMC 6772608. PMID 10924528.

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protein G(olf) subunit alpha is a protein that in humans is encoded by the GNAL gene. Its main product is the heterotrimeric G-protein alpha subunit Golf-α...

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Gsα is encoded by the GNAS complex locus, while Golfα is encoded by the GNAL gene. The general function of Gs is to activate intracellular signaling pathways...

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Dystonia

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alcohol. Other genes that have been associated with dystonia include CIZ1, GNAL, ATP1A3, and PRRT2. Another report has linked THAP1 and SLC20A2 to dystonia...

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Dawson Forest

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Lockheed, and was the previous site of the Georgia Nuclear Aircraft Laboratory (GNAL). The property is currently referred to as the Dawson Forest City of Atlanta...

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Heterotrimeric G protein

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stimulate neuronal activity, interleukin secretion by human leukocytes Golf αolf GNAL Activation of adenylate cyclase olfactory receptors, Dopamine D1-like receptors...

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Hoshimachi Suisei

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virtual YouTuber and self-proclaimed idol. She joined the VTuber agency S:gnal on 2 July 2018, but left a month later on 4 August. She released her first...

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Olfactory receptor neuron

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profiles. The activated OR in turn activates the intracellular G-protein, GOLF (GNAL), adenylate cyclase and production of cyclic AMP (cAMP) opens ion channels...

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A. Miculian: Copia dei Capitoli già stabiliti dall’ Ill. mo et ecc. mo Sig.r Antonio Barbaro Prov.re Gnal in Dalmatia, et Albania per gl’Haiduci v t e...

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Trond Andresen

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February 2009 Oppropet akademiskboikott.no [dead link] "LO ber Andresen droppe "gnål"-plakaten". Adresseavisen. Retrieved 10 May 2022. "Eksisterer det et norsk...

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tentpole franchise. In October, Firpo created the YouTube Original Series SiGNALS, a mixed-media extravaganza exploring climate change through the wild hopes...

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CHMP1B

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"C18orf2, a novel, highly conserved intronless gene within intron 5 of the GNAL gene on chromosome 18p11". Cytogenet. Cell Genet. 93 (1–2): 19–22. doi:10...

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Hirsch Sommerhausen

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society Ḥanokh la-naʿar ʿal pi darko (Dutch orthography: Chanoch Lanangar Gnal Pie Darkoo), which was dedicated to improving Jewish education and promoting...

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Nu Sigma Nu

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written to fit. One of them, to the tune of Auld Lang Syne, is called ENYS GNAL DLUA:: 386–391  Should auld acquaintance die away,     And friends be passers-by...

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Eby Friedman

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IEEE Workshop on SiGNAL PROCESSING SYSTEMS. SiPS 2000. Design and Implementation (Cat. No.00TH8528)". 2000 IEEE Workshop on SiGNAL PROCESSING SYSTEMS...

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