GZMB information

GZMB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FQ3, 1IAU
Identifiers
Aliases	GZMB, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, granzyme B, C11
External IDs	OMIM: 123910; MGI: 109267; HomoloGene: 108184; GeneCards: GZMB; OMA:GZMB - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	24,634,267 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	56,499,717 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; mononuclear cell; ; monocyte; ; spleen; ; bone marrow; ; decidua; ; lymph node; ; right lung; ; appendix;
	Top expressed in
	gastrula; ; jejunum; ; duodenum; ; decidua; ; blood; ; intestinal villus; ; embryo; ; pharynx; ; uterus; ; seminal vesicula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; protein binding; serine-type peptidase activity; serine-type endopeptidase activity; hydrolase activity;
Cellular component	cytosol; membrane; immunological synapse; nucleus; mitochondrion; secretory granule; cytoplasm;
Biological process	cytolysis; proteolysis; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; natural killer cell mediated cytotoxicity; apoptotic process; granzyme-mediated apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3002
	14939
	ENSG00000100453
	ENSMUSG00000015437
	P10144
	P04187
	NM_004131; NM_001346011
	NM_013542
	NP_001332940; NP_004122
	NP_038570
	Wikidata
View/Edit Human	View/Edit Mouse

Granzyme B is a serine protease that in humans is encoded by the GZMB gene.^[5] Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.

CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100453 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015437 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dahl CA, Bach FH, Chan W, Huebner K, Russo G, Croce CM, Herfurth T, Cairns JS (May 1990). "Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14". Hum Genet. 84 (5): 465–70. doi:10.1007/bf00195821. PMID 2323780. S2CID 22245529.
^ "Entrez Gene: GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100453 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015437 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2323780-5] Dahl CA, Bach FH, Chan W, Huebner K, Russo G, Croce CM, Herfurth T, Cairns JS (May 1990). "Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14". Hum Genet. 84 (5): 465–70. doi:10.1007/bf00195821. PMID 2323780. S2CID 22245529.

[6] "Entrez Gene: GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)".

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International Max Planck Research School for Molecular Biology