Global InformationLoin pain hematuria syndrome information
| Loin pain hematuria syndrome | |
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| Sagittal section of the kidney and its capsule. Pain in LPHS is thought to result from distension of the kidney capsule. | |
| Specialty | Urology |
Loin pain hematuria syndrome (LPHS) is the combination of debilitating unilateral or bilateral flank pain and microscopic or macroscopic amounts of blood in the urine that is otherwise unexplained.[1]
Loin pain-hematuria syndrome (LPHS) is a poorly defined disorder characterized by recurrent or persistent loin (flank) pain and hematuria that appears to represent glomerular bleeding. Most patients present with both manifestations, but some present with loin pain or hematuria alone. Pain episodes are rarely associated with low-grade fever and dysuria, but urinary tract infection is not present. The major causes of flank pain and hematuria, such as nephrolithiasis and blood clot, are typically not present. Renal arteriography may suggest focally impaired cortical perfusion, while renal biopsy may show interstitial fibrosis and arterial sclerosis.[2]
The pain is typically severe, and narcotic therapy is often prescribed as a way to manage chronic pain. Sleep can be difficult because the supine position increases pressure on the flank. The onset of pain is often associated with nausea and vomiting, making pain management by oral opiates complicated.[2]
- ^ Pukenas BA, Zaslau S (2003). "Loin pain hematuria syndrome: case series". W V Med J. 99 (5): 192–3. PMID 14959511.
- ^ a b "UpToDate". www.uptodate.com.