GRIN2A information

GRIN2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3NFL, 5H8Q, 5H8H, 5H8N, 5H8F, 5I2N, 5I2K, 5KDT, 5KCJ
Identifiers
Aliases	GRIN2A, EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A, glutamate ionotropic receptor NMDA type subunit 2A
External IDs	OMIM: 138253; MGI: 95820; HomoloGene: 645; GeneCards: GRIN2A; OMA:GRIN2A - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	10,182,928 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	9,813,424 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; endothelial cell; ; middle temporal gyrus; ; postcentral gyrus; ; lateral nuclear group of thalamus; ; superior frontal gyrus; ; primary visual cortex; ; entorhinal cortex; ; frontal pole; ; Brodmann area 46;
	Top expressed in
	Region I of hippocampus proper; ; primary motor cortex; ; subiculum; ; prefrontal cortex; ; lumbar subsegment of spinal cord; ; olfactory tubercle; ; hippocampus proper; ; piriform cortex; ; dentate gyrus; ; temporal lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium channel activity; zinc ion binding; NMDA glutamate receptor activity; metal ion binding; ion channel activity; protein binding; ionotropic glutamate receptor activity; cation channel activity; extracellularly glutamate-gated ion channel activity; amyloid-beta binding; glutamate-gated calcium ion channel activity; signaling receptor activity;
Cellular component	integral component of membrane; postsynaptic membrane; membrane; synaptic vesicle; postsynaptic density; plasma membrane; synapse; integral component of plasma membrane; NMDA selective glutamate receptor complex; cell surface; cell junction; endoplasmic reticulum; neuron projection; presynaptic membrane; postsynaptic density membrane; integral component of postsynaptic density membrane; synaptic membrane; glutamatergic synapse; cell projection; dendritic spine;
Biological process	visual learning; protein localization; glutamate receptor signaling pathway; neurogenesis; startle response; regulation of sensory perception of pain; positive regulation of long-term synaptic potentiation; negative regulation of protein catabolic process; response to amphetamine; regulation of membrane potential; directional locomotion; modulation of chemical synaptic transmission; memory; serotonin metabolic process; ion transport; learning; cation transmembrane transport; MAPK cascade; regulation of synaptic plasticity; sleep; dopamine metabolic process; ionotropic glutamate receptor signaling pathway; response to wounding; calcium ion transmembrane transport; locomotion; regulation of postsynaptic membrane potential; excitatory postsynaptic potential; learning or memory; positive regulation of apoptotic process; sensory perception of pain; response to ethanol; calcium ion transport; long-term potentiation; chemical synaptic transmission; positive regulation of GTPase activity; ion transmembrane transport; regulation of ion transmembrane transport; transport; brain development; calcium-mediated signaling; activation of cysteine-type endopeptidase activity; calcium ion transmembrane import into cytosol; excitatory chemical synaptic transmission; protein localization to postsynaptic membrane; cellular response to amyloid-beta; regulation of NMDA receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	2903
	14811
	ENSG00000183454
	ENSMUSG00000059003
	Q12879
	P35436
	NM_000833; NM_001134407; NM_001134408
	NM_008170
	NP_000824; NP_001127879; NP_001127880
	NP_032196
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamate [NMDA] receptor subunit epsilon-1 is a protein that in humans is encoded by the GRIN2A gene.^[5] With 1464 amino acids, the canonical GluN2A subunit isoform is large. GluN2A-short isoforms specific to primates can be produced by alternative splicing and contain 1281 amino acids.^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183454 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059003 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kalsi G, Whiting P, Bourdelles BL, Callen D, Barnard EA, Gurling H (February 1998). "Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels". Genomics. 47 (3): 423–425. doi:10.1006/geno.1997.5132. PMID 9480759.
^ Warming H, Pegasiou CM, Pitera AP, Kariis H, Houghton SD, Kurbatskaya K, et al. (July 2019). "A primate-specific short GluN2A-NMDA receptor isoform is expressed in the human brain". Molecular Brain. 12 (1): 64. doi:10.1186/s13041-019-0485-9. PMC 6610962. PMID 31272478.
^ Herbrechter R, Hube N, Buchholz R, Reiner A (July 2021). "Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data". Cellular and Molecular Life Sciences. 78 (14): 5605–5630. doi:10.1007/s00018-021-03865-z. PMC 8257547. PMID 34100982.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183454 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059003 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9480759-5] Kalsi G, Whiting P, Bourdelles BL, Callen D, Barnard EA, Gurling H (February 1998). "Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels". Genomics. 47 (3): 423–425. doi:10.1006/geno.1997.5132. PMID 9480759.

[6] Warming H, Pegasiou CM, Pitera AP, Kariis H, Houghton SD, Kurbatskaya K, et al. (July 2019). "A primate-specific short GluN2A-NMDA receptor isoform is expressed in the human brain". Molecular Brain. 12 (1): 64. doi:10.1186/s13041-019-0485-9. PMC 6610962. PMID 31272478.

[7] Herbrechter R, Hube N, Buchholz R, Reiner A (July 2021). "Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data". Cellular and Molecular Life Sciences. 78 (14): 5605–5630. doi:10.1007/s00018-021-03865-z. PMC 8257547. PMID 34100982.

GRIN2A information

and 18 Related for: GRIN2A information

GRIN2A

GRIN disorder

Attention deficit hyperactivity disorder

Ionotropic glutamate receptor

NMDA receptor

Causes of schizophrenia

Glutamate receptor

Causes of mental disorders

DLG4

GRIN2B

Interleukin 16

Index of biophysics articles

DLG3

PTK2B

GRIN2C

Lynette Sadleir

GRIN2D

FYN