dentate gyrus of hippocampal formation granule cell
neural layer of retina
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
ion channel activity
protein binding
extracellularly glutamate-gated ion channel activity
ionotropic glutamate receptor activity
NMDA glutamate receptor activity
glutamate-gated calcium ion channel activity
signaling receptor activity
Cellular component
integral component of membrane
postsynaptic membrane
membrane
plasma membrane
synapse
cell junction
intracellular anatomical structure
integral component of plasma membrane
NMDA selective glutamate receptor complex
postsynaptic density membrane
Biological process
startle response
regulation of sensory perception of pain
adult locomotory behavior
ion transport
MAPK cascade
ionotropic glutamate receptor signaling pathway
excitatory postsynaptic potential
calcium-mediated signaling
calcium ion transmembrane import into cytosol
regulation of molecular function
brain development
regulation of synaptic plasticity
long-term potentiation
excitatory chemical synaptic transmission
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2906
14814
Ensembl
ENSG00000105464
ENSMUSG00000002771
UniProt
O15399
Q03391
RefSeq (mRNA)
NM_000836
NM_008172
RefSeq (protein)
NP_000827
NP_032198
Location (UCSC)
Chr 19: 48.39 – 48.44 Mb
Chr 7: 45.83 – 45.88 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Glutamate [NMDA] receptor subunit epsilon-4 is a protein that in humans is encoded by the GRIN2D gene.[5][6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000105464 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000002771 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kalsi G, Whiting P, Bourdelles BL, Callen D, Barnard EA, Gurling H (Apr 1998). "Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels". Genomics. 47 (3): 423–5. doi:10.1006/geno.1997.5132. PMID 9480759.
^Watanabe T, Inoue S, Hiroi H, Orimo A, Kawashima H, Muramatsu M (Jan 1998). "Isolation of estrogen-responsive genes with a CpG island library". Mol. Cell. Biol. 18 (1): 442–9. doi:10.1128/mcb.18.1.442. PMC 121513. PMID 9418891.
^Cite error: The named reference entrez was invoked but never defined (see the help page).
receptor subunit epsilon-4 is a protein that in humans is encoded by the GRIN2D gene. N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate...
of these symptoms are variable. There are only a few cases reported for GRIN2D-related disorder so far; therefore, listed features may not accurately reflect...
subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). The NR2 subunit acts as the agonist binding site for glutamate, one of...
for mature IL-16. Interleukin 16 has been shown to interact with: GRIN2A, GRIN2D, KCNJ10, KCNJ15, Kir2.1, PPP1R12A, and PPP1R12B. GRCh38: Ensembl release...
subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). Variants of the gene are associated with the protective effect of coffee...
subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2C has been shown to interact with DLG4 and DLG3. Glutamate receptor...