A sensation of flashes or specks of dust (floaters); growing dark spot on the iris; change in the shape of the pupil; poor or blurry vision in one eye; loss of peripheral vision in one eye.
Complications
Retinal detachment
Usual onset
Visual abnormalities
Types
choroid, iris, and ciliary body
Diagnostic method
clinical examination by biomicroscopy and indirect ophthalmoscopy
Differential diagnosis
For choroid: choroidal tumors, especially choroidal nevus, metastatic tumors, choroidal hemangioma, and osteoma; hemorrhagic conditions like AMD and hemorrhagic choroidal detachment; retinal tumors such as congenital retinal pigment epithelium hypertrophy and retinal pigment epithelium adenocarcinoma; and inflammatory lesions like posterior scleritis. For iris: iris nevus, iris pigment epithelial cyst, iris stromal cyst, metastatic tumor of the iris, melanocytoma, iris atrophy and Cogan-Reese syndrome. For ciliary body: staphyloma, medulloepithelioma and leiomyoma.
Prevention
Reduce UV exposure to the eye.
Treatment
Brachytherapy, enucleation, proton beam radiotherapy, transpupillary thermotherapy, photocoagulation, photodynamic therapy, and local resection.
Frequency
5 cases per million people per year [2]
Uveal melanoma is a type of eye cancer in the uvea of the eye.[3] It is traditionally classed as originating in the iris, choroid, and ciliary body, but can also be divided into class I (low metastatic risk) and class II (high metastatic risk).[3] Symptoms include blurred vision, loss of vision or photopsia, but there may be no symptoms.[4]
Tumors arise from the pigment cells (melanocytes) that reside within the uvea and give color to the eye. These melanocytes are distinct from the retinal pigment epithelium cells underlying the retina that do not form melanomas. When eye melanoma is spread to distant parts of the body, the five-year survival rate is about 15%.[5]
It is the most common type of primary eye cancer.[3] Males and females are affected equally.[6] More than 50% spread, mostly to the liver.[6]
^"Uveal melanoma". www.cancer.gov. 2 February 2011. Retrieved 18 June 2023.
^Ocular Melanoma, National Organization for Rare Disorders, 2018
^ abcHarbour, J. William; Correa, Zelia M. (2021). "1. Molecular basis of uveal melanoma and emerging therapeutic targets". In Bernicker, Eric H. (ed.). Uveal Melanoma: Biology and Management. Switzerland: Springer. pp. 3–12. ISBN 978-3-030-78117-0.
^Sadowsky, Dylan; Delijani, Kevin; Lim, John; Cabrera, Matthew (22 July 2022). "Uveal Melanoma". Georgetown Medical Review. 6. doi:10.52504/001c.36973. S2CID 250996726.
^Eye Cancer Survival Rates, American Cancer Society, Last Medical Review: December 9, 2014 Last Revised: February 5, 2016
^ abDE, Elder; D, Massi; RA, Scolyer; R, Willemze (2018). "2. Melanocytic tumours: Ocular melanocytic tumours, uveal melanoma". WHO Classification of Skin Tumours. Vol. 11 (4th ed.). Lyon (France): World Health Organization. pp. 137–138. ISBN 978-92-832-2440-2.
Uvealmelanoma is a type of eye cancer in the uvea of the eye. It is traditionally classed as originating in the iris, choroid, and ciliary body, but can...
(/ˈjuːviə/; derived from Latin: uva meaning "grape"), also called the uveal layer, uveal coat, uveal tract, vascular tunic or vascular layer, is the pigmented middle...
childhood neuroblastoma; ovarian cancer; mammary adenocarcinoma; and uvealmelanoma. It is taken by mouth or by injection into a vein. Common side effects...
metastasis in uvealmelanomas. Moreover BAP1, GNAQ, GNA11, SF3B1 and EIF1AX gene alterations were shown to be in correlation with uvealmelanomas, each with...
melanosis (PAM), of which the latter is considered a risk factor for uvealmelanoma. The disease is caused by an increase of melanocytes in the iris, choroid...
the brand name Kimmtrak, is an anti-cancer medication used to treat uvealmelanoma (eye cancer). Tebentafusp is a bispecific gp100 peptide-HLA-directed...
Prof. Robert Aumann. Sacks underwent radiation therapy in 2006 for a uvealmelanoma in his right eye. He discussed his loss of stereoscopic vision caused...
but not in another A study found no association between alcohol and uvealmelanoma. A systematic review found evidence that light drinking may decrease...
iris may indicate the presence of a uveitis, and an increased risk of uvealmelanoma has been found in those with blue, green or gray eyes. However, a study...
molecular genetics of cancers, with particular interests in uvealmelanoma, conjunctival melanoma, intraocular and ocular adnexal lymphomas and CNS lymphoma...
to lung cancer. Choroidal metastases should be differentiated from uvealmelanoma, where the latter is a primary tumour arising from the choroid itself...
HLA-A*02:01-positive adult patients with unresectable or metastatic uvealmelanoma. Immunocore's other pipeline programs include IMC-C103C, an ImmTAC candidate...
control) than conventional radiotherapy. These include, among others, uvealmelanoma (ocular tumor), skull base and paraspinal tumor (chondrosarcoma and...
most important genetic alteration associated with poor prognosis in uvealmelanoma is loss of an entire copy of Chromosome 3 (Monosomy 3), which is strongly...
found in hemangiomas are also associated with port-wine stains and uvealmelanoma. As--the mostly juvenile--Waterhouse Friedrichsen Syndrome is caused...
Ned Eisenberg (January 13, 1957 – February 27, 2022) was an American actor known for his recurring role on Law & Order: Special Victims Unit as Roger Kressler...
the uvealmelanoma patients, suggesting that, besides being a metastasis suppressor, BAP1 could predispose certain people to more aggressive uveal melanoma...
accompanies phantom eye symptoms (PES) in patients undergoing enucleation for uvealmelanoma. While the exact nature of this relationship is complex, studies suggest...
in their BAP1 gene are at higher risk of developing mesothelioma and uvealmelanoma. Erionite is a zeolite mineral with similar properties to asbestos and...
Jacks, El Matador, and Pal's Lounge. Hackford died in April 2022 of uvealmelanoma in Sunset Beach, California, at the age of 51. Saperstein, Pat (April...
growth of GNAQ mutated uvealmelanoma cell lines. Furthermore, preliminary results suggest that selumetinib treatment of uvealmelanoma patients can result...
(removal of the maxilla). Cancer of the eye, such as retinoblastoma and uvealmelanoma Congenital cystic eye End-stage glaucoma Phthisis bulbi In cases of...
autobiography Baisers envolés in 2004. On 1 December 2006, Jade died of uvealmelanoma, which had metastasised to metastatic liver disease. She wore a prosthetic...
The Gαq / Gα11 (Q209L) mutation is associated with the development of uvealmelanoma and its pharmacological inhibition (cyclic depsipeptide FR900359 inhibitor)...
include uvealmelanoma (failed), and differentiated thyroid carcinoma. Trametinib (GSK1120212), FDA-approved to treat BRAF-mutated melanoma. Also studied...
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