RGS19 information

RGS19
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CMZ
Identifiers
Aliases	RGS19, GAIP, RGSGAIP, regulator of G-protein signaling 19, regulator of G protein signaling 19
External IDs	OMIM: 605071; MGI: 1915153; HomoloGene: 23320; GeneCards: RGS19; OMA:RGS19 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	64,079,988 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	181,335,770 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; spleen; ; bone marrow cells; ; parotid gland; ; trabecular bone; ; lymph node; ; amniotic fluid; ; appendix; ; right coronary artery;
	Top expressed in
	external carotid artery; ; spleen; ; blood; ; thymus; ; internal carotid artery; ; yolk sac; ; condyle; ; bone marrow; ; dermis; ; fossa;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity; protein binding; G-protein alpha-subunit binding; GTPase activity;
Cellular component	cytoplasm; Golgi apparatus; membrane; brush border; heterotrimeric G-protein complex; membrane raft; clathrin-coated vesicle; cytoplasmic vesicle; plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; small GTPase mediated signal transduction; autophagy; negative regulation of signal transduction; positive regulation of GTPase activity; response to ethanol;
	Sources:Amigo / QuickGO
Orthologs
	10287
	56470
	ENSG00000171700
	ENSMUSG00000002458
	P49795
	Q9CX84
	NM_001039467; NM_005873
NM_001291205; NM_001291206; NM_001291207; NM_001291208; NM_001291209;
	NM_001291210; NM_026446
	NP_001034556; NP_005864
NP_001278134; NP_001278135; NP_001278136; NP_001278137; NP_001278138;
	NP_001278139; NP_080722
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of G-protein signaling 19 is a protein that in humans is encoded by the RGS19 gene.^[5]^[6]

G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling.^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171700 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002458 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ De Vries L, Mousli M, Wurmser A, Farquhar MG (January 1996). "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain". Proc Natl Acad Sci U S A. 92 (25): 11916–20. doi:10.1073/pnas.92.25.11916. PMC 40514. PMID 8524874.
^ ^a ^b "Entrez Gene: RGS19 regulator of G-protein signalling 19".
^ Berman DM, Wilkie TM, Gilman AG (1996). "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits". Cell. 86 (3): 445–452. doi:10.1016/S0092-8674(00)80117-8. PMID 8756726. S2CID 12427406.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171700 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002458 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8524874-5] De Vries L, Mousli M, Wurmser A, Farquhar MG (January 1996). "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain". Proc Natl Acad Sci U S A. 92 (25): 11916–20. doi:10.1073/pnas.92.25.11916. PMC 40514. PMID 8524874.

[entrez-6] "Entrez Gene: RGS19 regulator of G-protein signalling 19".

[7] Berman DM, Wilkie TM, Gilman AG (1996). "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits". Cell. 86 (3): 445–452. doi:10.1016/S0092-8674(00)80117-8. PMID 8756726. S2CID 12427406.

RGS19 information

and 9 Related for: RGS19 information

RGS19

Regulator of G protein signaling

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GIPC1

OSTM1

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GIPC3

GNAI3