GJA5 information

GJA5
Identifiers
Aliases	GJA5, ATFB11, CX40, gap junction protein alpha 5
External IDs	OMIM: 121013; MGI: 95716; HomoloGene: 3856; GeneCards: GJA5; OMA:GJA5 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	147,773,362 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	96,984,732 bp
RNA expression pattern
	Top expressed in
	placenta; ; right coronary artery; ; left coronary artery; ; right auricle; ; lower lobe of lung; ; popliteal artery; ; tibial arteries; ; upper lobe of lung; ; Descending thoracic aorta; ; upper lobe of left lung;
	Top expressed in
	yolk sac; ; vascular endothelium; ; vasculature of trunk; ; footplate; ; dorsal aorta; ; atrium; ; primordial ventricle; ; tongue muscle; ; myocardium of atrium; ; abdominal aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	gap junction channel activity involved in cardiac conduction electrical coupling; gap junction channel activity; gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling; gap junction hemi-channel activity; gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling; gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling; gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling; gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling; disordered domain specific binding; connexin binding;
Cellular component	integral component of membrane; cell projection; membrane; intercalated disc; plasma membrane; integral component of plasma membrane; cell junction; gap junction; connexin complex;
Biological process	bundle of His cell to Purkinje myocyte communication by electrical coupling; skeletal system development; regulation of ventricular cardiac muscle cell membrane depolarization; cardiac conduction system development; ventricular septum development; negative regulation of blood pressure; ventricular septum morphogenesis; SA node cell action potential; AV node cell to bundle of His cell communication; regulation of atrial cardiac muscle cell membrane depolarization; ventricular cardiac muscle cell action potential; cell communication by electrical coupling involved in cardiac conduction; outflow tract morphogenesis; atrial ventricular junction remodeling; cell communication by electrical coupling; mitral valve development; pulmonary valve formation; embryonic heart tube development; regulation of Purkinje myocyte action potential; atrial septum morphogenesis; cell communication; potassium ion transport; regulation of bundle of His cell action potential; heart development; regulation of renin secretion into blood stream; blood vessel development; cardiac conduction; embryonic limb morphogenesis; protein complex oligomerization; AV node cell to bundle of His cell communication by electrical coupling; positive regulation of vasoconstriction; angiogenesis; artery morphogenesis; transmembrane transport; endothelium development; renal system process involved in regulation of systemic arterial blood pressure; regulation of systemic arterial blood pressure; gap junction assembly; positive regulation of cell communication by chemical coupling; cell communication involved in cardiac conduction; regulation of cardiac muscle contraction; septum primum development; regulation of heart rate by cardiac conduction; regulation of AV node cell action potential; negative regulation of glomerular filtration; atrial septum development; vasomotion; foramen ovale closure; cell communication by chemical coupling; regulation of atrial cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization; regulation of membrane depolarization during cardiac muscle cell action potential; SA node cell to atrial cardiac muscle cell communication by electrical coupling; atrial cardiac muscle cell to AV node cell communication by electrical coupling; Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling; blood vessel diameter maintenance;
	Sources:Amigo / QuickGO
Orthologs
	2702
	14613
	ENSG00000265107
	ENSMUSG00000057123
	P36382
	Q01231
	NM_005266; NM_181703
	NM_001271628; NM_008121
	NP_005257; NP_859054
	NP_001258557; NP_032147
	Wikidata
View/Edit Human	View/Edit Mouse

Gap junction alpha-5 protein (GJA5), also known as connexin 40 (Cx40) — is a protein that in humans is encoded by the GJA5 gene.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000265107 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057123 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000265107 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057123 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

GJA5 information

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