Neonatal diabetes mellitus (NDM) is a disease that affects an infant and their body's ability to produce or use insulin. NDM is a kind of diabetes that is monogenic (regulated by a single gene) and arises in the first 6 months of life. Infants do not produce enough insulin, leading to an increase in glucose accumulation. It is a rare disease, occurring in only one in 100,000 to 500,000 live births.[1] NDM can be mistaken for the much more common type 1 diabetes, but type 1 diabetes usually occurs later than the first 6 months of life. There are two types of NDM: permanent neonatal diabetes mellitus (PNDM), a lifelong condition, and transient neonatal diabetes mellitus (TNDM), a form of diabetes that disappears during the infant stage but may reappear later in life.[1]
Specific genes that can cause NDM have been identified.[2] The onset of NDM can be caused by abnormal pancreatic development, beta cell dysfunction or accelerated beta cell dysfunction.[3] Along with maturity-onset diabetes of the young (MODY), NDM is a form of monogenic diabetes. Individuals with monogenic diabetes can pass it on to their children or future generations. Each gene associated with NDM has a different inheritance pattern.
^ ab"Monogenic Forms of Diabetes | NIDDK". National Institute of Diabetes and Digestive and Kidney Diseases. Retrieved 2017-11-05.
^Monogenic Forms of Diabetes: Neonatal Diabetes Mellitus and Maturity-onset Diabetes of the Young Archived 2015-04-19 at the Wayback Machine at National Diabetes Information Clearinghouse, a service of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health. NIH Publication No. 07–6141. March 2007. Copyright cite: This publication is not copyrighted.
^"Neonatal diabetes - Other types of diabetes mellitus - Diapedia, The Living Textbook of Diabetes". www.diapedia.org. Archived from the original on 2017-12-13. Retrieved 2017-11-06.
Neonataldiabetes mellitus (NDM) is a disease that affects an infant and their body's ability to produce or use insulin. NDM is a kind of diabetes that...
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such as in type 1 diabetes or post-pancreatectomy.[citation needed] Sulfonylureas can be used to treat some types of neonataldiabetes. Historically, people...
S2CID 23520352. Jones CW (September 2001). "Gestational diabetes and its impact on the neonate". Neonatal Network. 20 (6): 17–23. doi:10.1891/0730-0832.20.6...
mutations in hyper- and hypoglycemia: maturity-onset diabetes of the young, permanent neonataldiabetes, and hyperinsulinemia of infancy". Human Mutation...
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and homozygous variant of PDX1 can cause dysgenesis of pancreas and neonataldiabetes. CDH2 (CD352) gene encoded Neural-cadherin (N-cadherin) is identified...
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