Biological effects of radiation on the epigenome information
Ionizing radiation can cause biological effects which are passed on to offspring through the epigenome. The effects of radiation on cells has been found to be dependent on the dosage of the radiation, the location of the cell in regards to tissue, and whether the cell is a somatic or germ line cell. Generally, ionizing radiation appears to reduce methylation of DNA in cells.[1]
Ionizing radiation has been known to cause damage to cellular components such as proteins, lipids, and nucleic acids. It has also been known to cause DNA double-strand breaks. Accumulation of DNA double strand breaks can lead to cell cycle arrest in somatic cells and cause cell death. Due to its ability to induce cell cycle arrest, ionizing radiation is used on abnormal growths in the human body such as cancer cells, in radiation therapy. Most cancer cells are fully treated with some type of radiotherapy, however some cells such as stem cell cancer cells show a reoccurrence when treated by this type of therapy.[1]
^ abKim, Joong-Gook; Park, Moon-Taek; Heo, Kyu; Yang, Kwang-Mo; Yi, Joo Mi (2013-07-18). "Epigenetics Meets Radiation Biology as a New Approach in Cancer Treatment". International Journal of Molecular Sciences. 14 (7): 15059–15073. doi:10.3390/ijms140715059. ISSN 1422-0067. PMC 3742287. PMID 23873297.
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