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Atheroma information


Atheroma
Other namesatheromata (plural), atheromas (plural), atheromatous plaque, plaque
Atherosclerotic plaque from a carotid endarterectomy specimen. This shows the division of the common into the internal and external carotid arteries.
SpecialtyCardiology Edit this on Wikidata
ComplicationsThrombosis, embolism, atherosclerosis, arteriosclerosis
CausesHyperlipidemia, hypertriglyceridemia, hypercholesterolemia

An atheroma, or atheromatous plaque, is an abnormal accumulation of material in the inner layer of an arterial wall.[1][2]

The material consists of mostly macrophage cells,[3][4] or debris, containing lipids, calcium and a variable amount of fibrous connective tissue. The accumulated material forms a swelling in the artery wall, which may intrude into the lumen of the artery, narrowing it and restricting blood flow. Atheroma is the pathological basis for the disease entity atherosclerosis, a subtype of arteriosclerosis.[5]

  1. ^ Lusis, Aldons J. (September 2000). "Atherosclerosis". Nature. 407 (6801): 233–241. doi:10.1038/35025203. PMC 2826222. PMID 11001066.
  2. ^ Francis, Andrew A; Pierce, Grant N (2011). "An integrated approach for the mechanisms responsible for atherosclerotic plaque regression". Experimental & Clinical Cardiology. 16 (3): 77–86. ISSN 1205-6626. PMC 3209544. PMID 22065938.
  3. ^ Hotamisligil, Gökhan S (April 2010). "Endoplasmic reticulum stress and atherosclerosis". Nature Medicine. 16 (4): 396–399. doi:10.1038/nm0410-396. PMC 2897068. PMID 20376052.
  4. ^ Oh, Jisu; Riek, Amy E.; Weng, Sherry; Petty, Marvin; Kim, David; Colonna, Marco; Cella, Marina; Bernal-Mizrachi, Carlos (6 April 2012). "Endoplasmic Reticulum Stress Controls M2 Macrophage Differentiation and Foam Cell Formation". Journal of Biological Chemistry. 287 (15): 11629–11641. doi:10.1074/jbc.M111.338673. PMC 3320912. PMID 22356914.
  5. ^ dos Santos, Vanessa Prado; Pozzan, Geanete; Castelli, Valter; Caffaro, Roberto Augusto (2021). "Arteriosclerosis, atherosclerosis, arteriolosclerosis, and Monckeberg medial calcific sclerosis: what is the difference?". Jornal Vascular Brasileiro. 20: e20200211. doi:10.1590/1677-5449.200211. ISSN 1677-5449. PMC 8276643. PMID 34290756.

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Atheroma

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An atheroma, or atheromatous plaque, is an abnormal accumulation of material in the inner layer of an arterial wall. The material consists of mostly macrophage...

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Atherosclerosis

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muscular layer, specifically in the muscle cells adjacent to atheromas and on the surface of atheroma plaques and tissue. In time, as cells die, this leads to...

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Cardiac arrest

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Cardiac arrest, also known as sudden cardiac arrest, is when the heart suddenly and unexpectedly stops beating. As a result, blood cannot properly circulate...

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Panoramic radiograph

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have the capability to demonstrate a portion of the neck and display atheromas (calcifications in the carotid artery) which are an indication of both...

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Lacunar stroke

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stenosis). Occasionally, atheroma in the parent artery blocks the orifice of the penetrating artery (luminal atheroma), or atheroma involves the origin of...

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Vulnerable plaque

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contribute to a high mechanical stress zone on the fibrous cap of the atheroma, making it prone to rupture. Increased hemodynamic stress, e.g. increased...

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Coronary catheterization

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deals with most commonly occur as a result of advanced atherosclerosis – atheroma activity within the wall of the coronary arteries. Less frequently, valvular...

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Coronary circulation

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obstructed by an atheroma, the second artery is still able to supply oxygenated blood to the myocardium. However, this can only occur if the atheroma progresses...

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Angiography

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of the artery openings. The presence or absence of atherosclerosis or atheroma within the walls of the arteries cannot be clearly determined. Coronary...

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Cholesterol

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concentrations of functional HDL, which can remove cholesterol from cells and atheromas, offer protection and are commonly referred to as "good cholesterol"....

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Endarterectomy

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additional strokes.[citation needed] Coronary endarterectomy involves removing atheroma from the wall of blocked blood vessels (coronary) supplying the heart muscle...

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Fibrous cap

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cap contains macrophages and smooth muscle cells. The fibrous cap of an atheroma is composed of bundles of muscle cells, macrophages, foam cells, lymphocytes...

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Thrombus

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and aggregation; Common causes include: trauma, smoking, hypertension, atheroma. Hemodynamic changes (stasis, turbulence): Blood stasis promotes greater...

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Artery

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is a disease marked by the hardening of arteries. This is caused by an atheroma or plaque in the artery wall and is a build-up of cell debris, that contain...

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Trodusquemine

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Parkinson's model; prevention of aortic valve calcification in a mouse atheroma model; stimulation of T-cell anti-tumor immunity in a mouse model; correction...

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Blood

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reduces the flow of blood through arteries, because atheroma lines arteries and narrows them. Atheroma tends to increase with age, and its progression can...

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Plaque

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Plaquette, a small plaque in bronze or other materials Amyloid plaque Atheroma or atheromatous plaque, a buildup of deposits within the wall of an artery...

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Blood pressure

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growth (atheroma) that develops within the walls of arteries. The higher the pressure, the more stress that is present and the more atheroma tend to progress...

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Bruit

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the aorta Hepatocellular carcinoma Alcoholic hepatitis Atherosclerosis (atheroma or plaque) (cholesterol deposition in artery wall) Median arcuate ligament...

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Cardiovascular disease

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Arteriosclerosis Atherosclerosis Foam cell Fatty streak Atheroma Intermittent claudication Critical limb ischemia Monckeberg's arteriosclerosis Arteriolosclerosis...

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Encephalomalacia

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softening. Each case was similar to the previous article. There was some atheroma in the internal brain arteries that led to the cerebral softening of the...

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Acute coronary syndrome

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other conditions. In those who have ACS, atheroma rupture is most commonly found 60% when compared to atheroma erosion (30%), thus causes the formation...

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Stenosis

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Arteriosclerosis Atherosclerosis Foam cell Fatty streak Atheroma Intermittent claudication Critical limb ischemia Monckeberg's arteriosclerosis Arteriolosclerosis...

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Aortic dissection

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Arteriosclerosis Atherosclerosis Foam cell Fatty streak Atheroma Intermittent claudication Critical limb ischemia Monckeberg's arteriosclerosis Arteriolosclerosis...

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Glycocalyx

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detrimental effects that can cause disease. Certain stimuli that cause atheroma may lead to enhanced sensitivity of vasculature. Initial dysfunction of...

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Hypertension

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Arteriosclerosis Atherosclerosis Foam cell Fatty streak Atheroma Intermittent claudication Critical limb ischemia Monckeberg's arteriosclerosis Arteriolosclerosis...

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Aneurysm

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Arteriosclerosis Atherosclerosis Foam cell Fatty streak Atheroma Intermittent claudication Critical limb ischemia Monckeberg's arteriosclerosis Arteriolosclerosis...

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Hypertriglyceridemia

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fatty liver disease, atherosclerosis, alcoholism, metabolic syndrome Differential diagnosis Hyperlipidemia, atheroma, hypercholesterolemia, hypercalcemia...

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Dystrophic calcification

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brain. Dense scars may undergo hyaline degeneration and calcification. Atheroma in aorta and coronaries frequently undergo calcification. Cysts can show...

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