A cartoon depiction of the enzyme ferredoxin hydrogenase
Identifiers
EC no.
1.12.7.2
CAS no.
9080-02-8
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In enzymology, ferredoxin hydrogenase (EC 1.12.7.2), also referred to as [Fe-Fe]hydrogenase, H2 oxidizing hydrogenase, H2 producing hydrogenase, bidirectional hydrogenase, hydrogenase (ferredoxin), hydrogenlyase, and uptake hydrogenase, is found in Clostridium pasteurianum, Clostridium acetobutylicum,Chlamydomonas reinhardtii, and other organisms. The systematic name of this enzyme is hydrogen:ferredoxin oxidoreductase[1][2]
Ferredoxin hydrogenase belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with an iron-sulfur protein as acceptor. Ferredoxin hydrogenase has an active metallocluster site referred to as an "H-cluster" or "H domain" that is involved in the inter-conversion of protons and electrons with hydrogen gas.
^Artz JH, Zadvornyy OA, Mulder DW, Keable SM, Cohen AE, Ratzloff MW, et al. (January 2020). "Tuning Catalytic Bias of Hydrogen Gas Producing Hydrogenases". Journal of the American Chemical Society. 142 (3): 1227–1235. doi:10.1021/jacs.9b08756. PMC 8653774. PMID 31816235.
^Lorent C, Katz S, Duan J, Kulka CJ, Caserta G, Teutloff C, et al. (March 2020). "Shedding light on proton and electron dynamics in [FeFe] hydrogenases". Journal of the American Chemical Society. 142 (12): 5493–5497. doi:10.1021/jacs.9b13075. PMID 32125830. S2CID 212407474.
and 23 Related for: Ferredoxin hydrogenase information
enzymology, ferredoxinhydrogenase (EC 1.12.7.2), also referred to as [Fe-Fe] hydrogenase, H2 oxidizing hydrogenase, H2 producing hydrogenase, bidirectional...
[FeFe]-hydrogenases perform hydrogen turnover using ferredoxin as a redox partner while bifurcating types perform the same reaction using both ferredoxin and...
Bidirectional hydrogenase may refer to: Ferredoxinhydrogenase, an enzyme Hydrogen dehydrogenase, an enzyme This disambiguation page lists articles associated...
Ferredoxins (from Latin ferrum: iron + redox, often abbreviated "fd") are iron–sulfur proteins that mediate electron transfer in a range of metabolic...
H2 producing hydrogenase may refer to: Ferredoxinhydrogenase, an enzyme Hydrogenase (acceptor), an enzyme This set index page lists enzyme articles associated...
full range of enzymes needed to perform the nitrogen fixation: ferredoxin, hydrogenase, and an important enzyme nitrogenase. The process of nitrogen fixation...
Hydrogen lyase may refer to: Ferredoxinhydrogenase, an enzyme Hydrogenase (acceptor), an enzyme This set index page lists enzyme articles associated...
many hydrogenases, such as a 5,10-methenyltetrahydromethanopterin hydrogenase, a ferredoxinhydrogenase (eha), and a coenzyme F420 hydrogenase. Proteomic...
demonstrated for the first time the presence of pyruvate:ferredoxin oxido-reductase and hydrogenase in eukaryotes. Further studies were subsequently conducted...
NAD+ from NADH. Electrons are transferred to ferredoxin, or can be directly accepted from NADH by a hydrogenase, producing H2. Because of this most of the...
work and ones that do not. Some anaerobic organisms use NADP+-linked hydrogenase, ripping a hydride from hydrogen gas to produce a proton and NADPH. Like...
more than the Thauer limit (>4 mol H2 /mol glucose). It employs [FeFe]-hydrogenases to produce hydrogen gas (H2) by fermenting many different types of carbohydrates...
(F6P) activated lactate dehydrogenase; H2 by pyruvate ferredoxin oxidoreductase and hydrogenase; and ethanol via NADH- and NADPH-linked alcohol dehydrogenase...
pyruvate-ferredoxin oxidoreductase, producing CO2 gas and reduced ferredoxin. Electrons from the reduced ferredoxin are transferred to protons by hydrogenase,...
iron became limited. Ferredoxin is iron-dependant as well as oxidant-sensitive. Under these limited iron conditions, ferredoxin was no longer preferred...
(2022). "Second and Outer Coordination Sphere Effects in Nitrogenase, Hydrogenase, Formate Dehydrogenase, and CO Dehydrogenase". Chemical Reviews. 122...
proposed, including Ferredoxin, NADP+/NADPH and flavoprotein complexes like flavin adenine dinucleotide (FAD) as well as hydrogenases. CODHs support the...
regenerate NAD+ from NADH. Electrons are transferred to ferredoxin, which in turn is oxidized by hydrogenase, producing H2. Hydrogen gas is a substrate for methanogens...
They do not require oxygen and instead use pyruvate:ferredoxin oxido-reductase and hydrogenase to produce ATP from pyruvate, generating hydrogen gas...
aldehyde ferredoxin oxidoreductase, or AOR, which utilizes tungsten, sulfur, and iron to catalyze the oxidation of aldehydes and reduce ferredoxin (this...
which converts CO2 and hydrogen gas into methane and H2O. 7 different hydrogenases are present in M. maripaludis that allow for the usage of H2 as an electron...
membrane-bound hydrogenase causing proton pumping via electron transfer to various quinones and cytochromes. In many organisms, a second cytoplasmic hydrogenase is...
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