Familial British dementia is a form of dementia. It was first reported by Cecil Charles Worster-Drought in 1933 [1] and is therefore also known as Worster-Drought syndrome. It is caused by a mutation in the ITM2B gene (also known as BRI2); a different mutation of the same gene causes the similar syndrome of familial Danish dementia. The combination of amyloid pathology and neurofibrillary tangles has led to comparison with the pathology of Alzheimer's disease.[2]
^C Worster-Drought; Hill, TR; McMenemey, WH; et al. (1933). "Familial Presenile Dementia with Spastic Paralysis". J Neurol Psychopathol. s1-14 (53): 27–34. doi:10.1136/jnnp.s1-14.53.27. PMC 1038860. PMID 21610757.
FamilialBritishdementia is a form of dementia. It was first reported by Cecil Charles Worster-Drought in 1933 and is therefore also known as Worster-Drought...
Familial Danish dementia is an extremely rare, neurodegenerative disease characterized by progressive cataracts, loss of hearing, cerebellar ataxia, paranoid...
located on chromosome 13. The gene is connected to familial Danish dementia and familialBritishdementia causing amyloid and pre-filbrillar effects similar...
these diseases are mainly sporadic and only a few cases are familial. Others are only familial. Some result from medical treatment. Prions are an infectious...
survival by about a year. A higher proportion of frontotemporal dementias seem to have a familial component than other neurodegenerative diseases such as Alzheimer's...
trouble sleeping as its hallmark symptom. The majority of cases are familial (fatal familial insomnia [FFI]), stemming from a mutation in the PRNP gene, with...
Dementia with Lewy bodies (DLB) is a type of dementia characterized by changes in sleep, behavior, cognition, movement, and regulation of automatic bodily...
caused by the same amyloid protein that is associated with Alzheimer's dementia, brain bleeds are more common in people who have a diagnosis of Alzheimer's...
progressive supranuclear palsy, corticobasal degeneration, familial frontotemporal dementia, and Creutzfeldt–Jakob disease. In a small study of 5 retired...
Neil Rossor FRCP FMedSci, is a British clinical neurologist with a specialty interest in degenerative dementias and familial disease. He is professor emeritus...
syndrome, fatal familial insomnia, and kuru, as well as the recently discovered variably protease-sensitive prionopathy and familial spongiform encephalopathy...
feature dysautonomia, such as Parkinson's disease, multiple system atrophy, dementia with Lewy bodies, Ehlers–Danlos syndromes, autoimmune autonomic ganglionopathy...
while people with hundreds or thousands of repeats can have familial ALS, frontotemporal dementia, or sometimes sporadic ALS. The three mechanisms of disease...
of familial cases of ALS, as well as a small percentage of sporadic cases; it also causes about 25% of familial cases of frontotemporal dementia. The...
chaperone function. These include BRI2, which is related to familialBritish and Danish dementia (FBD and FDD); Chondromodulin-I, related to chondrosarcoma;...
degeneration (FTLD) is a pathological process that occurs in frontotemporal dementia. It is characterized by atrophy in the frontal lobe and temporal lobe of...
Younger People with Dementia and later worked with smaller dementia charities while also functioning as an independent advocate for dementia caregivers. As...
its variant (vCJD), Gerstmann–Sträussler–Scheinker syndrome (GSS), fatal familial insomnia (FFI), and kuru. There is also evidence suggesting prions may...
involving over 65,000 people concluded that Statins decreased the risk of dementia, Alzheimer's disease, and even improved cognitive impairment in some cases...
Atrial fibrillation is associated with an increased risk of heart failure, dementia, and stroke. It is a type of supraventricular tachycardia. High blood pressure...
2016 (2016-09-18) When her elderly mother disappeared, Ghazal Mansury blamed dementia. But as this documentary reveals, the rest of her family suspected something...
Orzabal, died in July 2017 aged 54 after suffering from alcoholism-related dementia and cirrhosis, which came about after being diagnosed with depression....
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