FHL3 information

FHL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WYH, 2CUQ, 2EHE
Identifiers
Aliases	FHL3, SLIM2, four and a half LIM domains 3
External IDs	OMIM: 602790; MGI: 1341092; HomoloGene: 37928; GeneCards: FHL3; OMA:FHL3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	38,005,606 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	124,602,404 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; vastus lateralis muscle; ; thoracic diaphragm; ; triceps brachii muscle; ; deltoid muscle; ; tibialis anterior muscle; ; left uterine tube; ; ascending aorta; ; popliteal artery; ; right coronary artery;
	Top expressed in
	lip; ; esophagus; ; yolk sac; ; urethra; ; skeletal muscle tissue; ; male urethra; ; morula; ; aortic valve; ; thymus; ; quadriceps femoris muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding; protein binding; metal ion binding;
Cellular component	Z disc; nucleus; stress fiber; focal adhesion;
Biological process	muscle organ development; actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	2275
	14201
	ENSG00000183386
	ENSMUSG00000032643
	Q13643; Q96C98
	Q9R059
	NM_004468; NM_001243878
	NM_010213
	NP_001230807; NP_004459; NP_001230807.1
	NP_034343
	Wikidata
View/Edit Human	View/Edit Mouse

Four and a half LIM domains protein 3 is a protein that in humans is encoded by the FHL3 gene.^[5]^[6]^[7]

LIM proteins are defined by the possession of a highly conserved double zinc finger motif called the LIM domain.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183386 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032643 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Morgan MJ, Madgwick AJ (October 1996). "Slim defines a novel family of LIM-proteins expressed in skeletal muscle". Biochem Biophys Res Commun. 225 (2): 632–8. doi:10.1006/bbrc.1996.1222. PMID 8753811.
^ Lee SM, Tsui SK, Chan KK, Kotaka M, Li HY, Chim SS, Waye MM, Fung KP, Lee CY (May 1999). "Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1". Somat Cell Mol Genet. 24 (3): 197–202. doi:10.1023/B:SCAM.0000007122.03392.4b. PMID 10226657. S2CID 40511123.
^ ^a ^b "Entrez Gene: FHL3 four and a half LIM domains 3".

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