Fasciculation and elongation protein zeta-1 is a protein that in humans is encoded by the FEZ1 gene.[5][6][7]
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.[7]
This protein is present in neurons, and it is believed to block the process of infection of these cells by HIV.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000149557 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032118 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Bloom L, Horvitz HR (May 1997). "The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation". Proc Natl Acad Sci U S A. 94 (7): 3414–9. Bibcode:1997PNAS...94.3414B. doi:10.1073/pnas.94.7.3414. PMC 20384. PMID 9096408.
^Suzuki T, Okada Y, Semba S, Orba Y, Yamanouchi S, Endo S, Tanaka S, Fujita T, Kuroda S, Nagashima K, Sawa H (Jun 2005). "Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation". J Biol Chem. 280 (26): 24948–56. doi:10.1074/jbc.M411499200. PMID 15843383.
^ ab"Entrez Gene: FEZ1 fasciculation and elongation protein zeta 1 (zygin I)".
^Haedicke, J.; Brown, C.; Naghavi, M. H. (Aug 2009). "The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection". Proceedings of the National Academy of Sciences. 106 (33): 14040–14045. Bibcode:2009PNAS..10614040H. doi:10.1073/pnas.0900502106. ISSN 0027-8424. PMC 2729016. PMID 19667186.
elongation protein zeta-1 is a protein that in humans is encoded by the FEZ1 gene. This gene is an ortholog of the C. elegans unc-76 gene, which is necessary...
Haedicke J, Brown C, Naghavi MH (August 2009). "The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection". Proceedings...
(FEZ1). FEZ1 is a mammalian homolog of the C. elegans UNC-76 protein involved in axonal outgrowth and fasciculation. The C-terminal region of FEZ1 (aa...
Rattan S, Inoue H, Mori M, Fidanza V, Alder H, Croce CM (May 1999). "The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression...
cargo receptor in selective autophagy. NBR1 has been shown to interact with FEZ1. GRCh38: Ensembl release 89: ENSG00000188554 – Ensembl, May 2017 GRCm38:...
associated with TEDC2. TEDC2 also interacts with FEZ1, a fasciculation and elongation protein. FEZ1, or fasciculation and elongation protein 1, is necessary...
(2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally...
2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally...
for at least one virus species' agnoprotein include p53, Ku70, PP2A, YB-1, FEZ1, HP1α, α-SNAP, PCNA, and AP-3. In some cases, the agnogene itself has functional...
Rattan S, Inoue H, Mori M, Fidanza V, Alder H, Croce CM (May 1999). "The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression...
skeleton. PAM16 has been known to interact with PAM18, DNAJC19, TIMM17A, FEZ1, TRIM25, MARC1, and other proteins. ENSG00000282228 GRCh38: Ensembl release...
Okumura F, Hatakeyama S, Matsumoto M, et al. (2005). "Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis". J...
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