DRAP1 information

DRAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JFI
Identifiers
Aliases	DRAP1, NC2-alpha, DR1 associated protein 1
External IDs	OMIM: 602289; MGI: 1913806; HomoloGene: 4703; GeneCards: DRAP1; OMA:DRAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	65,921,563 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,475,007 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; granulocyte; ; right hemisphere of cerebellum; ; right frontal lobe; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; apex of heart; ; prefrontal cortex; ; C1 segment;
	Top expressed in
	muscle of thigh; ; triceps brachii muscle; ; dentate gyrus of hippocampal formation granule cell; ; medial head of gastrocnemius muscle; ; yolk sac; ; sternocleidomastoid muscle; ; neural layer of retina; ; superior frontal gyrus; ; temporal muscle; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein heterodimerization activity; protein binding; DNA-binding transcription factor activity; transcription corepressor activity; DNA binding; identical protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; chromatin binding; transcription coactivator activity; transcription factor binding; transcription coregulator activity;
Cellular component	nucleus;
Biological process	transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; RNA polymerase II preinitiation complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	10589
	66556
	ENSG00000175550
	ENSMUSG00000024914
	Q14919
	Q9D6N5
	NM_006442
	NM_001291080; NM_024176
	NP_006433
	NP_001278009; NP_077138
	Wikidata
View/Edit Human	View/Edit Mouse

Dr1-associated corepressor is a protein that in humans is encoded by the DRAP1 gene.^[5]^[6]

Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175550 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024914 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mermelstein F, Yeung K, Cao J, Inostroza JA, Erdjument-Bromage H, Eagelson K, et al. (April 1996). "Requirement of a corepressor for Dr1-mediated repression of transcription". Genes & Development. 10 (8): 1033–48. doi:10.1101/gad.10.8.1033. PMID 8608938.
^ ^a ^b "Entrez Gene: DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175550 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024914 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8608938-5] Mermelstein F, Yeung K, Cao J, Inostroza JA, Erdjument-Bromage H, Eagelson K, et al. (April 1996). "Requirement of a corepressor for Dr1-mediated repression of transcription". Genes & Development. 10 (8): 1033–48. doi:10.1101/gad.10.8.1033. PMID 8608938.

[entrez-6] "Entrez Gene: DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)".

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