Example representation of the environmental factors characterizing the exposome.
The exposome is a concept used to describe environmental exposures that an individual encounters throughout life, and how these exposures impact biology and health. It encompasses both external and internal factors, including chemical, physical, biological, and social factors that may influence human health.[1][2][3]
The study of the exposome has become a useful tool in understanding the interplay between genetics and environmental factors in the development of diseases, with a particular focus on chronic conditions.[4] The concept has been widely applied in fields such as epidemiology, toxicology, and public health, among others, and has led to significant advances[5] in our understanding of disease etiology and prevention.
By considering the cumulative effect of multiple exposures, it provides a holistic approach to the study of gene-environment interactions, allowing for a more accurate assessment[6] of disease risk and the identification of potential intervention strategies.[7]
Environmental exposures can have a significant impact on an individual's health. Exposure to air pollution, for example, has been linked to an increased risk of respiratory disease, heart disease, and even premature death. Similarly, exposure to certain chemicals in consumer products has been linked to an increased risk of cancer and other health problems.[5] In addition to external factors, the internal exposome can also influence an individual's health outcomes. For example, genetics can play a role in how an individual's body processes and responds to environmental exposures,[7] while the gut microbiome can affect an individual's immune system and overall health. As our understanding of the exposome continues to evolve, it is likely that we will gain new insights into the complex interplay between our environment and our health.
^Wild CP (August 2005). "Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology". Cancer Epidemiology, Biomarkers & Prevention. 14 (8): 1847–1850. doi:10.1158/1055-9965.epi-05-0456. PMID 16103423. S2CID 6446979.
^Ottinger MA, Geiselman C (2022). ONE HEALTH AND THE EXPOSOME: Human, wildlife, and ecosystem health. [S.l.]: Elsevier Academic Press. ISBN 978-0-323-89873-7. OCLC 1276932534.
^Miller GW (2020). The exposome: a new paradigm for the environment and health (Second ed.). London, United Kingdom. ISBN 978-0-12-814080-2. OCLC 1156991933.{{cite book}}: CS1 maint: location missing publisher (link)
^Rappaport SM, Barupal DK, Wishart D, Vineis P, Scalbert A (August 2014). "The blood exposome and its role in discovering causes of disease". Environmental Health Perspectives. 122 (8): 769–774. doi:10.1289/ehp.1308015. PMC 4123034. PMID 24659601.
^Miller GW, Jones DP (January 2014). "The nature of nurture: refining the definition of the exposome". Toxicological Sciences. 137 (1): 1–2. doi:10.1093/toxsci/kft251. PMC 3871934. PMID 24213143.
^ abVrijheid M, Slama R, Robinson O, Chatzi L, Coen M, van den Hazel P, et al. (June 2014). "The human early-life exposome (HELIX): project rationale and design". Environmental Health Perspectives. 122 (6): 535–544. doi:10.1289/ehp.1307204. PMC 4048258. PMID 24610234.
The exposome is a concept used to describe environmental exposures that an individual encounters throughout life, and how these exposures impact biology...
The exposome encompasses the set of human environmental (i.e. non-genetic) exposures from conception onwards, complementing the genome. The exposome was...
past three decades, including the beginnings of the formation of the "exposome". However, there is still much unknown and research in the field is only...
features can also vary over time due to aging, skin care, nutrition, the exposome (such as harmful substances of the general environment, workplace and cosmetics)...
individual ("the unique disease principle"), considering uniqueness of the exposome (a totality of endogenous and exogenous / environmental exposures) and...
University College Groningen Campus Fryslân [nl] Exposome-NL, Dutch consortium cooperating in the field of exposome research. The University of Groningen engages...
and molecular components are organized to optimally respond to distinct exposome challenges. Currently, several types of IR are classified. Type 1 IR is...
medicine) Dose–response relationship Excitotoxicity Environment and health Exposome Insect toxin List of highly toxic gases List of poisonous plants Pollution...
molecular pathology is diverse, so as inter-personal difference in the exposome, which influence disease processes through the interactome within the tissue...
clusters of sporadic ALS: Pathway to discovery of etiology via lifetime exposome research". Frontiers in Neuroscience. 17: 1005096. doi:10.3389/fnins.2023...
cumulative lifetime of exposures to environmental factors, termed their exposome. The most consistent lifetime exposures associated with developing ALS...
inflammaging) due to unresolved acute inflammation and an individual's exposome. Age-related systemic chronic inflammation is associated with several cytokines...
measure of the proportion of money invested in the same industry sector Exposome Exposure of the dead, or sky burial Expose (disambiguation) This disambiguation...
Environmental health Environmental toxicology Enzyme inhibition Exposure science Exposome Forensic toxicology History of poison In vitro toxicology Indicative limit...
Resource Integrated Database Environmental agreement Environmental racism Exposome Global Atmosphere Watch Global dimming Great Smog of London Haze Health...
equation Biological computation BioSystems (journal) Computational biology Exposome Interactome List of omics topics in biology List of systems biology modeling...
Utrecht, the Netherlands in the field of environmental epidemiology and exposome. His scientific research focuses on environmental risk factors for cancer...
of greater use in medicine as it correlates strongly with risk-related exposomes that are potentially heritable when they become embodied in the epigenome...
InChI CAS PubChem "TTD". 37,316 T3DB Toxin and Toxin-Target Database Toxic Exposome Database University of Alberta toxins and toxin targets T3D "T3DB". 3,678...
leads to heritable cognitive deficits in mice – and more broadly that the exposome of men may also affect the mental health of the next generation (19 Sep)...
pharmacovigilance and to explore trends in medicines usage. Epidemiology Exposome International Society for Pharmacoepidemiology Molecular epidemiology Molecular...
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